Altamura A C, Gomeni R, Sacchetti E, Smeraldi E
Eur J Clin Pharmacol. 1977 Aug 17;12(1):59-63. doi: 10.1007/BF00561406.
Five healthy volunteers were treated orally with lithium carbonate, sulphate, or chloride. There were no significant differences in area under time-concentration curves, half-lives, total body clearance or apparent distribution volumes between the various salts, either in plasma or in the RBC compartment. The carbonate salt did show a higher RBC/plasma distribution ratio than the other salts, which might possibly imply greater therapeutic effectiveness of this salt. Some considerations on the tolerability of various lithium salts are discussed.
五名健康志愿者口服碳酸锂、硫酸锂或氯化锂进行治疗。在血浆或红细胞区室中，不同盐类之间的时间-浓度曲线下面积、半衰期、全身清除率或表观分布容积均无显著差异。碳酸盐盐类的红细胞/血浆分布比确实高于其他盐类，这可能意味着该盐类具有更高的治疗效果。文中还讨论了对各种锂盐耐受性的一些考量。
