Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426 Ibrahimia, 21321 Alexandria, Egypt; Department of Chemistry, Rabigh College of Science and Art, King Abdulaziz University, Saudi Arabia.
Bacteriology Unit, Botany Department, Faculty of Science, Tanta University, Tanta 31527, Egypt; Department of Chemistry, Rabigh College of Science and Art, King Abdulaziz University, Saudi Arabia.
J Photochem Photobiol B. 2018 Oct;187:48-53. doi: 10.1016/j.jphotobiol.2018.07.029. Epub 2018 Aug 4.
The [Ag(Menic)(ClO)], (1) and [Ag(NA)]ClO, (2) complexes, where Menic; methylnicotinate and NA; nicotinamide, were synthesized and characterized using elemental analysis, FTIR, NMR and single crystal X-ray diffraction combined with DFT calculations. The Ag(I) is coordinated with two organic ligand molecules in both complexes. In 1, the coordination sphere is completed by one ClO¯ anion as a monodentate ligand while in 2, the ClO¯ anion is in the outer sphere. Both complexes showed some argentophilic interactions where the AgAg distance is shorter in 1 (3.152(6) Å) than 2 (3.303(9) Å). The organic ligands showed no antimicrobial activity up to 15 mmole/L while both silver(I) complexes are biologically active against different bacterial strains and the fungus Candida albicans. The minimal inhibition concentrations (MICs) of the Ag(I) complexes are in the range of 4-8 mmol/L depending on the nature of microorganism. Complex 2 showed slightly better antifungal action than 1. In contrast, complex 1 showed higher antibacterial potency against P. aeruginosa, C. perfringens, Sh. sonnei and Str. pneumonia compared to 2. The antibacterial action of 2 is slightly higher or equal against the rest of microorganisms compared to 1. The strength and nature of the AgAg, AgN and Ag…O interactions were analyzed using atoms in molecules and natural bond orbital calculations.
[Ag(Menic)(ClO)]，（1）和[Ag(NA)]ClO，（2）配合物，其中 Menic；烟酰甲胺和 NA；烟酰胺，使用元素分析、FTIR、NMR 和单晶 X 射线衍射结合 DFT 计算进行了合成和表征。Ag(I)在两个配合物中与两个有机配体分子配位。在 1 中，配位球由一个 ClO¯阴离子作为单齿配体完成，而在 2 中，ClO¯阴离子在外部球中。两个配合物都显示出一些银-银相互作用，其中 1 中的 AgAg 距离更短（3.152(6) Å）比 2（3.303(9) Å）。在 15mmole/L 以下，有机配体没有显示出任何抗菌活性，而两个银（I）配合物对不同的细菌菌株和真菌白色念珠菌都具有生物活性。Ag(I)配合物的最小抑制浓度（MICs）在 4-8mmol/L 范围内，具体取决于微生物的性质。与 1 相比，2 显示出略好的抗真菌作用。相比之下，1 对铜绿假单胞菌、产气荚膜梭菌、伤寒沙门氏菌和肺炎链球菌的抗菌活性高于 2。2 对其余微生物的抗菌作用略高或等于 1。使用分子中的原子和自然键轨道计算分析了 AgAg、AgN 和 Ag…O 相互作用的强度和性质。
