Wang Shi, Ding Hao, Li Longsong, Zhao Ruifang, Chai Ningli
Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China.
Graduate School of the People's Liberation Army (PLA) General Hospital, Beijing, 100853, PR China.
Mater Today Bio. 2025 Apr 30;32:101820. doi: 10.1016/j.mtbio.2025.101820. eCollection 2025 Jun.
is a significant risk factor for gastric cancer, making its elimination crucial for prevention. This review explores the application of nanotechnology in enhancing treatment efficacy against and addressing antibiotic resistance. Nanomaterials are utilized as drug carriers to protect pharmaceuticals from the acidic gastric environment and enable controlled release. These materials can be specifically engineered to target surface molecules, thereby improving antimicrobial efficacy. Enhanced drug penetration is achieved by optimizing the surface properties and molecular architecture of nanomaterials. Additional strategies include targeting virulence factors, such as urease and vacuolating cytotoxin A, as well as inhibiting bacterial proliferation through reactive oxygen species-based therapies. Moreover, the ability of nanomaterials to effectively modulate the microbiota and inhibit pathogens has shown great potential in the application of combating . By focusing on specific invasion mechanisms and metabolic pathways, nanotechnology offers significant promise for advancing treatments against . Despite its potential, several challenges remain, including high drug development costs, difficulties in precise targeting, and adverse effects associated with certain approaches, such as photothermal therapy. Ongoing optimization of nanotechnological strategies is anticipated to address these challenges, thereby facilitating the development of more effective and targeted therapies for infection.
是胃癌的一个重要风险因素，因此消除它对于预防胃癌至关重要。本综述探讨了纳米技术在提高针对的治疗效果和解决抗生素耐药性方面的应用。纳米材料被用作药物载体，以保护药物免受酸性胃环境的影响并实现控释。这些材料可以经过特殊设计以靶向表面分子，从而提高抗菌效果。通过优化纳米材料的表面性质和分子结构来实现增强的药物渗透。其他策略包括靶向毒力因子，如尿素酶和空泡毒素A，以及通过基于活性氧的疗法抑制细菌增殖。此外，纳米材料有效调节微生物群和抑制病原体的能力在对抗的应用中显示出巨大潜力。通过关注特定的入侵机制和代谢途径，纳米技术在推进针对的治疗方面具有重大前景。尽管具有潜力，但仍存在一些挑战，包括药物开发成本高、精确靶向困难以及与某些方法（如光热疗法）相关的不良反应。预计对纳米技术策略的持续优化将解决这些挑战，从而促进开发更有效和有针对性的治疗感染的方法。
