Department of Anatomic Pathology, IRCCS Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli, 8, Roma I-00168, Italy; Roma ENETS Center of Excellence, IRCCS Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli, 8, Roma I-00168, Italy; Gynecological and Breast Pathology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli, 8, Roma I-00168, Italy.
Department of Anatomic Pathology, IRCCS Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli, 8, Roma I-00168, Italy; Roma ENETS Center of Excellence, IRCCS Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli, 8, Roma I-00168, Italy; Anatomic Pathology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli, 8, Roma I-00168, Italy.
Endocrinol Metab Clin North Am. 2018 Sep;47(3):463-470. doi: 10.1016/j.ecl.2018.04.008. Epub 2018 Jul 11.
Based on the 2010 version, the 2017 World Health Organization (WHO 2017) classification is for pancreatic neuroendocrine neoplasms (PanNEN). The WHO 2017 classification introduces the novel well-differentiated neuroendocrine tumor of high grade (NET G3). A sharp distinction between NET and poorly differentiated neuroendocrine carcinoma (NEC) is emphasized to highlight substantial biological differences. Further changes comprise the definition of mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN), to accommodate all grades of both neoplasm components, and the abolition of preneoplastic lesions given their rarity in the pancreas. The 2017 American Joint Cancer Committee classification (AJCC 2017) adopts such a classification for all digestive sites.
基于 2010 年版，2017 年世界卫生组织（WHO 2017）分类是用于胰腺神经内分泌肿瘤（PanNEN）的。WHO 2017 分类引入了新型高级别分化良好的神经内分泌肿瘤（NET G3）。强调了 NET 与低分化神经内分泌癌（NEC）的明显区别，以突出其生物学上的显著差异。进一步的变化包括混合性神经内分泌-非神经内分泌肿瘤（MiNEN）的定义，以适应两种肿瘤成分的所有级别，并取消了因在胰腺中罕见而被认为是癌前病变的病变。2017 年美国癌症联合委员会分类（AJCC 2017）采用了这种分类方法，适用于所有消化道部位。
