Unité Populations virales et pathogenèse, Institut Pasteur, Paris, France.
Unité Populations virales et pathogenèse, Institut Pasteur, Paris, France.
Curr Opin Virol. 2018 Dec;33:74-80. doi: 10.1016/j.coviro.2018.07.014. Epub 2018 Aug 9.
Particles containing degenerate forms of the viral genome which interfere with virus replication and are non-replicative per se are known as defective interfering particles (DIPs). DIPs are likely to be produced upon infection by any virus in vitro and in nature. Until recently, roles of these non-viable particles as members of a multi-component viral system have been overlooked. In this review, we cover the most recent studies that shed light on critical roles of DIPs during the course of infection, including: the modulation of virus replication, innate immune responses, disease outcome and virus persistence, as well as the evolution of the viral population. Together, these reports allow us to conceive a more complete picture of the virion population, and highlight the fact that DIPs are not a negligible subset of this population but instead can greatly influence the fate of infection.
已知含有病毒基因组退化形式的颗粒会干扰病毒复制，且本身是非复制的，这些颗粒被称为缺陷干扰颗粒（DIP）。DIP 可能在体外和自然感染任何病毒时产生。直到最近，这些非活性颗粒作为多组分病毒系统成员的作用才被忽视。在这篇综述中，我们涵盖了最近的研究，这些研究揭示了 DIP 在感染过程中的关键作用，包括：病毒复制、先天免疫反应、疾病结果和病毒持续存在的调节，以及病毒群体的进化。这些报告使我们能够对病毒群体有一个更完整的认识，并强调这样一个事实，即 DIP 不是这个群体中可以忽略不计的一部分，而是可以极大地影响感染的命运。
