Kidokoro Y, Kravis T C, Moser K M, Taylor J C, Crawford I P
Am Rev Respir Dis. 1977 May;115(5):793-803. doi: 10.1164/arrd.1977.115.5.793.
In 9 alpha1-antitrypsin-deficient (PiZZ) persons 40 to 53 years of age, the relationships between the concentration of elastolytic protease of polymorphonuclear leukocyte granules and cigarette smoking, and the degree of abnormality in detailed pulmonary function tests were explored. Regardless of the statistical analytic approach used, elastase concentration was related more frequently and significantly than smoking history to the degree of abnormality observed in tests of pulmonary function. The data suggest that the severity of pulmonary dysfunction in PiZZ persons may be determined by variables other than age and cigarette smoking, including the concentration of elastolytic protease in leukocyte lysosomes.
在9名年龄在40至53岁的α1-抗胰蛋白酶缺乏症（PiZZ型）患者中，研究了多形核白细胞颗粒弹性蛋白酶浓度与吸烟之间的关系，以及详细肺功能测试中的异常程度。无论采用何种统计分析方法，与吸烟史相比，弹性蛋白酶浓度与肺功能测试中观察到的异常程度之间的相关性更频繁且更显著。数据表明，PiZZ型患者肺功能障碍的严重程度可能由年龄和吸烟以外的其他变量决定，包括白细胞溶酶体中弹性蛋白酶的浓度。
