Theobald R J, Hoffman V
Life Sci. 1986 Apr 28;38(17):1591-5. doi: 10.1016/0024-3205(86)90498-4.
In the present study the possibility of provoking an irreversible blockade of P2-receptors in vivo by photolyzing ANAPP3 was investigated. ANAPP3 administered as an intraarterial infusion produced a short-lived blockade of P2-receptor mediated contractions of cat urinary bladders in situ. However, irradiation of the bladders with visible light during the infusion of ANAPP3 resulted in a blockade of the response for at least 120 minutes. Thus, photoactivation of ANAPP3 in vivo produced an essentially irreversible blockade of P2-purinergic receptors.
在本研究中，研究了通过光解ANAPP3在体内引发P2受体不可逆阻断的可能性。以动脉内输注方式给予的ANAPP3对猫原位膀胱P2受体介导的收缩产生了短暂的阻断作用。然而，在输注ANAPP3期间用可见光照射膀胱导致反应阻断至少持续120分钟。因此，ANAPP3在体内的光激活产生了对P2嘌呤能受体基本上不可逆的阻断。
