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芳基叠氮基氨基丙酰基三磷酸腺苷(ANAPP3)对猫膀胱收缩的拮抗作用。

Arylazido aminopropionyl atp (ANAPP3) antagonism of cat urinary bladder contractions.

作者信息

Theobald R J

出版信息

J Auton Pharmacol. 1982 Sep;2(3):175-9. doi: 10.1111/j.1474-8673.1982.tb00487.x.

DOI:10.1111/j.1474-8673.1982.tb00487.x
PMID:7142232
Abstract

ANAPP3 produces a transient contraction of the urinary bladder of the cat similar to that produced by ATP and hypogastric nerve stimulation. 2 ANAPP3 partially antagonizes the inhibition of pelvic nerve-evoked bladder contractions induced by adenosine, possibly by blocking P1 receptors. 3 ANAPP3 antagonizes contractions of the cat urinary bladder induced by ATP, beta, gamma-methylene ATP, pelvic nerve stimulation and hypogastric nerve stimulation. 4 ANAPP3 produces no antagonism of either noradrenaline-induced inhibition of pelvic nerve-evoked bladder contractions or acetylcholine-induced bladder contractions, thereby substantiating the specificity of the effect of ANAPP3 against purines.

摘要

血管活性肠肽(ANAPP3)可使猫的膀胱产生短暂收缩,类似于三磷酸腺苷(ATP)和腹下神经刺激所引起的收缩。2. ANAPP3可部分拮抗腺苷对盆神经诱发膀胱收缩的抑制作用,可能是通过阻断P1受体实现的。3. ANAPP3可拮抗由ATP、β,γ-亚甲基ATP、盆神经刺激和腹下神经刺激所引起的猫膀胱收缩。4. ANAPP3对去甲肾上腺素引起的盆神经诱发膀胱收缩的抑制作用或乙酰胆碱引起的膀胱收缩均无拮抗作用,从而证实了ANAPP3对嘌呤作用的特异性。

相似文献

1
Arylazido aminopropionyl atp (ANAPP3) antagonism of cat urinary bladder contractions.芳基叠氮基氨基丙酰基三磷酸腺苷(ANAPP3)对猫膀胱收缩的拮抗作用。
J Auton Pharmacol. 1982 Sep;2(3):175-9. doi: 10.1111/j.1474-8673.1982.tb00487.x.
2
The effect of arylazido aminopropionyl ATP (ANAPP3) on inhibition of pelvic nerve evoked contractions of the cat urinary bladder.芳基叠氮氨基丙酰ATP(ANAPP3)对猫膀胱盆神经诱发收缩的抑制作用。
Eur J Pharmacol. 1986 Jan 29;120(3):351-4. doi: 10.1016/0014-2999(86)90476-0.
3
The effect of arylazido aminopropionyl ATP on atropine resistant contractions of the cat urinary bladder.芳基叠氮氨基丙酰三磷酸腺苷对猫膀胱阿托品抵抗性收缩的影响。
Life Sci. 1983 May 23;32(21):2479-84. doi: 10.1016/0024-3205(83)90374-0.
4
Evidence against purinergic nerve fibres in the hypogastric nerves of the cat.反对猫腹下神经中嘌呤能神经纤维存在的证据。
J Auton Pharmacol. 1983 Dec;3(4):235-9. doi: 10.1111/j.1474-8673.1983.tb00540.x.
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Stimulation of lumbar sympathetic nerves evokes contractions of cat colon circular muscle mediated by ATP and noradrenaline.刺激猫的腰交感神经会引发由三磷酸腺苷(ATP)和去甲肾上腺素介导的结肠环行肌收缩。
Br J Pharmacol. 1993 Nov;110(3):1260-70. doi: 10.1111/j.1476-5381.1993.tb13951.x.
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Long-lasting blockade of P2-receptors of the urinary bladder in vivo following photolysis of arylazido aminopropionyl ATP, a photoaffinity label.在光解芳叠氮基氨丙酰ATP(一种光亲和标记物)后,膀胱P2受体在体内被长期阻断。
Life Sci. 1986 Apr 28;38(17):1591-5. doi: 10.1016/0024-3205(86)90498-4.
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Comparison of the effects of apamin, a Ca2+-dependent K+ channel blocker, and arylazido aminopropionyl ATP (ANAPP3), a P2-purinergic receptor antagonist, in the guinea-pig vas deferens.豚鼠输精管中钙依赖性钾通道阻滞剂蜂毒明肽与P2嘌呤能受体拮抗剂芳基叠氮氨基丙酰ATP(ANAPP3)作用效果的比较。
Eur J Pharmacol. 1984 Sep 17;104(3-4):327-34. doi: 10.1016/0014-2999(84)90409-6.
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Pharmacological studies to examine the source of ATP released by pelvic nerve stimulation in the feline lower urinary tract.药理学研究以探究猫下尿路盆神经刺激释放的ATP来源。
J Auton Pharmacol. 1996 Apr;16(2):111-5. doi: 10.1111/j.1474-8673.1996.tb00419.x.
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Arylazido aminopropionyl ATP (ANAPP3): interaction with adenosine receptors in longitudinal smooth muscle of the guinea-pig ileum.芳基叠氮氨基丙酰基三磷酸腺苷(ANAPP3):与豚鼠回肠纵行平滑肌中腺苷受体的相互作用。
Eur J Pharmacol. 1986 Apr 29;123(3):395-400. doi: 10.1016/0014-2999(86)90714-4.
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Interaction of [3H]arylazido aminopropionyl ATP ([3H]ANAPP3) with P2-purinergic receptors in the smooth muscle of the isolated guinea-pig vas deferens.[3H]芳基叠氮氨基丙酰ATP([3H]ANAPP3)与离体豚鼠输精管平滑肌中P2嘌呤能受体的相互作用。
Eur J Pharmacol. 1985 Jan 15;108(1):49-61. doi: 10.1016/0014-2999(85)90282-1.

引用本文的文献

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Purinergic signalling in the urinary tract in health and disease.健康与疾病状态下尿路中的嘌呤能信号传导。
Purinergic Signal. 2014 Mar;10(1):103-55. doi: 10.1007/s11302-013-9395-y. Epub 2013 Nov 22.
2
5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle.5-羟色胺受体可促进豚鼠离体逼尿肌中的兴奋性神经肌肉传递。
Br J Pharmacol. 1995 Jun;115(4):677-83. doi: 10.1111/j.1476-5381.1995.tb14986.x.
3
Non-adrenergic, non-cholinergic control of the urinary bladder.
膀胱的非肾上腺素能、非胆碱能控制
World J Urol. 1994;12(5):233-44. doi: 10.1007/BF00191202.
4
The effects of nicotine on spontaneous contractions of cat urinary bladder in situ.尼古丁对猫原位膀胱自发性收缩的影响。
Br J Pharmacol. 1984 Oct;83(2):347-55. doi: 10.1111/j.1476-5381.1984.tb16494.x.
5
Electrical and mechanical responses of guinea-pig bladder muscle to nerve stimulation.豚鼠膀胱肌肉对神经刺激的电反应和机械反应。
Br J Pharmacol. 1989 Dec;98(4):1083-90. doi: 10.1111/j.1476-5381.1989.tb12651.x.