中国汉族人群中VEGFA基因多态性与坏死性小肠结肠炎的关联
Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population.
作者信息
Gao Xiaoyan, Ma Fei, Hao Hu, Dai Yiheng, Liu Weidong, Xiao Xin, Gao Pingmin, Li Sitao
机构信息
Department of Neonatology, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, China.
Department of Neonatology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
出版信息
Pediatr Neonatol. 2019 Apr;60(2):129-134. doi: 10.1016/j.pedneo.2018.07.002. Epub 2018 Jul 19.
BACKGROUND
To examine whether polymorphisms in the VEGFA gene lead to low VEGFA production in peripheral blood and increased risk of NEC in the Chinese Han population.
MATERIAL AND METHODS
Thirty NEC patients and 80 control subjects were enrolled. Six VEGFA single-nucleotide polymorphisms (SNPs) were performed using the SEQUENOM MassARRAY platform assay. The concentration of VEGFA in the plasma was measured using an enzyme-linked immunosorbent assay.
RESULTS
The rs699947 and rs833061 VEGF-A SNPs were found to be associated with low plasma levels and high risk of NEC.
CONCLUSION
Our results suggested that, if validated in larger studies, screening for VEGFA SNPs and plasma levels might be useful as a risk factor for NEC in the future.
背景
研究血管内皮生长因子A（VEGFA）基因多态性是否会导致中国汉族人群外周血中VEGFA生成量降低以及坏死性小肠结肠炎（NEC）风险增加。
材料与方法
纳入30例NEC患者和80例对照受试者。使用SEQUENOM MassARRAY平台分析法检测6个VEGFA单核苷酸多态性（SNP）。采用酶联免疫吸附测定法测量血浆中VEGFA的浓度。
结果
发现VEGF-A的rs699947和rs833061 SNP与血浆水平降低及NEC高风险相关。
结论
我们的结果表明，如果在更大规模的研究中得到验证，筛查VEGFA SNP和血浆水平可能在未来作为NEC的一个风险因素具有实用价值。
Zotero 插件