Duarte Paulo Schiavom, de Castroneves Luciana Audi, Sado Heitor Naoki, Sapienza Marcelo Tatit, de Oliveira Hoff Ana Amélia Fialho, Buchpiguel Carlos Alberto
1Division of Nuclear Medicine, São Paulo Cancer Institute (ICESP), Av. Dr. Arnaldo, 251, 4° SS, Cerqueira César, São Paulo, SP 01246-000 Brazil.
2Division of Endocrinology, São Paulo Cancer Institute (ICESP), São Paulo, Brazil.
Nucl Med Mol Imaging. 2018 Aug;52(4):318-323. doi: 10.1007/s13139-018-0527-8. Epub 2018 Jun 4.
Herein, we report a case of a 19-year-old man with multiple endocrine neoplasia type 2B (MEN2B) and medullary thyroid carcinoma (MTC) diagnosed when he was 12 years of age. The patient had previously undergone total thyroidectomy, cervical radiotherapy, and chemotherapy. He progressed with known bone, pulmonary, and lymph node metastases and was scanned with F-fluoride (F-NaF) and Ga-dotatate whole-body positron emission tomography/computed tomography (PET/CT) for metastatic disease monitoring. We found that the MTC bone metastases and soft tissue calcified metastases were better characterized on F-NaF PET/CT than on Ga-dotatate PET/CT. This case illustrates that the F-NaF PET/CT could be helpful not only to the detection of bone metastases but also to the detection of calcified soft tissue metastases in patients with MTC.
在此，我们报告一例19岁男性病例，其在12岁时被诊断为2B型多发性内分泌腺瘤病（MEN2B）和甲状腺髓样癌（MTC）。该患者此前已接受全甲状腺切除术、颈部放疗和化疗。他出现了已知的骨、肺和淋巴结转移，并接受了F - 氟化物（F - NaF）和镓 - 奥曲肽全身正电子发射断层扫描/计算机断层扫描（PET/CT）以监测转移性疾病。我们发现，与镓 - 奥曲肽PET/CT相比，F - NaF PET/CT对MTC骨转移和软组织钙化转移的特征显示更佳。该病例表明，F - NaF PET/CT不仅有助于检测MTC患者的骨转移，还有助于检测钙化的软组织转移。
