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[脑膜黑素细胞瘤：良性肿瘤的侵袭性演变：附2例报告]

[Meningeal melanocytoma: aggressive evolution of a benign tumor: about 2 cases].

作者信息

Khoulali Mohamed, Haouas Mohammed Yasssine, Mortada Jihad, Srour Robin

机构信息

Université Mohammed Premier, Faculté de Médecine et de Pharmacie, CHU Mohamed VI, Oujda, Maroc.

Université Hassan II, CHU Ibn Rochd, Casablanca, Maroc.

出版信息

Pan Afr Med J. 2018 Apr 11;29:211. doi: 10.11604/pamj.2018.29.211.10680. eCollection 2018.

DOI:10.11604/pamj.2018.29.211.10680
PMID:30100965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6080982/
Abstract

Meningeal melanocytomas are rare pigmented tumors affecting the central nervous system and developing in the cerebrospinal leptomeninges. We report two cases of meningeal melanocytomas showing very marked disparity in their evolution: a very long-term development of meningocerebral lesion, with malignant transformation resulting in the death of the first patient after 32 years and intramedullary ectopic location with very fast massive meningeal diffusion in the second patient. These two cases show the uncertain evolutive profile of meningeal melanocytomas. These lesions may become aggressive with poor prognosis despite an intensive therapeutic strategy.

摘要

脑膜黑素细胞瘤是一种罕见的色素性肿瘤，累及中枢神经系统，发生于脑脊膜。我们报告两例脑膜黑素细胞瘤，其病程差异显著：第一例患者的脑膜脑病变长期发展，发生恶性转化，32年后死亡；第二例患者肿瘤位于髓内异位，脑膜迅速广泛扩散。这两例病例显示了脑膜黑素细胞瘤病程的不确定性。尽管采取了积极的治疗策略，这些病变仍可能进展为侵袭性病变，预后不良。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d035/6080982/ee06b8fdcd40/PAMJ-29-211-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d035/6080982/1754ae41bcdf/PAMJ-29-211-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d035/6080982/157cfd57d965/PAMJ-29-211-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d035/6080982/bb46c8b1c36a/PAMJ-29-211-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d035/6080982/161a6329e575/PAMJ-29-211-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d035/6080982/ee06b8fdcd40/PAMJ-29-211-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d035/6080982/1754ae41bcdf/PAMJ-29-211-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d035/6080982/157cfd57d965/PAMJ-29-211-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d035/6080982/bb46c8b1c36a/PAMJ-29-211-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d035/6080982/161a6329e575/PAMJ-29-211-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d035/6080982/ee06b8fdcd40/PAMJ-29-211-g005.jpg

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本文引用的文献

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Primary intramedullary melanocytoma in the cervical spinal cord: Case report and literature review.颈髓原发性髓内黑素细胞瘤：病例报告及文献复习
Radiol Case Rep. 2015 Dec 3;10(1):1010. doi: 10.2484/rcr.v10i1.1010. eCollection 2015.
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Malignant transformation of intracranial meningeal melanocytoma. Case report and review of the literature.颅内脑膜黑色素细胞瘤的恶性转化。病例报告及文献复习。
Neuropathology. 2011 Aug;31(4):414-20. doi: 10.1111/j.1440-1789.2010.01160.x. Epub 2010 Nov 9.
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Melanocytoma of cerebellum.
Indian J Pathol Microbiol. 2008 Jan-Mar;51(1):47-8. doi: 10.4103/0377-4929.40394.
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Loss of expression of protein kinase a regulatory subunit 1alpha in pigmented epithelioid melanocytoma but not in melanoma or other melanocytic lesions.蛋白激酶A调节亚基1α在色素性上皮样黑素细胞瘤中表达缺失，但在黑色素瘤或其他黑素细胞性病变中无此现象。
Am J Surg Pathol. 2007 Nov;31(11):1764-75. doi: 10.1097/PAS.0b013e318057faa7.
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The 2007 WHO classification of tumours of the central nervous system.2007年世界卫生组织中枢神经系统肿瘤分类
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Malignant transformation of meningeal melanocytoma: a case report.脑膜黑素细胞瘤的恶性转化：一例报告
Brain Tumor Pathol. 2003;20(1):21-5. doi: 10.1007/BF02478943.
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Meningeal melanocytoma: an aggressive course for a benign tumor.脑膜黑素细胞瘤：一种良性肿瘤的侵袭性病程。
J Neurooncol. 2003 Sep;64(3):259-63. doi: 10.1023/a:1025628802228.
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Paramagnetic metal scavenging by melanin: MR imaging.黑色素对顺磁性金属的清除作用：磁共振成像
Radiology. 1997 Aug;204(2):417-23. doi: 10.1148/radiology.204.2.9240529.
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Meningeal melanocytoma: diagnostic criteria for a rare lesion.
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