Bustamante-Córdova Lorena, Melgoza-González Edgar A, Hernández Jesús
Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, Hermosillo, Mexico.
Front Vet Sci. 2018 Jul 27;5:175. doi: 10.3389/fvets.2018.00175. eCollection 2018.
The production of recombinant antibodies has had a tremendous impact on several research fields, most prominently in biotechnology, immunology and medicine, enabling enormous advances in each. Thus far, a broad diversity of recombinant antibody (rAb) forms have been designed and expressed using different expression systems. Even though the majority of rAbs approved for clinical use are targeted to humans, advances in veterinary medicine seem promising. The aim of this mini-review is to present an update regarding the rAbs in veterinary medicine reported to date, as well as their potential use in diagnostics, prophylaxis and therapeutics. Full- and single-chain fragment variables are the most common forms of rAbs developed for the detection, prevention and control of parasitic, bacterial and viral diseases, as well as pain and cancer treatment. Nonetheless, advances in research seem to be skewed toward economically important animals, such as pigs, cows, poultry and dogs. Although significant results have been obtained from the rAbs reported here, most have not been developed enough to be approved. Further research and clinical trials should be encouraged to enable important findings to fulfill their intended potential to improve animal well-being.
重组抗体的生产对多个研究领域产生了巨大影响，在生物技术、免疫学和医学领域最为显著，推动了这些领域的巨大进步。到目前为止，人们已经利用不同的表达系统设计并表达了多种形式的重组抗体（rAb）。尽管大多数获批用于临床的rAb是针对人类的，但兽医学领域的进展似乎很有前景。本综述的目的是介绍迄今为止报道的兽医学中rAb的最新情况，以及它们在诊断、预防和治疗方面的潜在用途。全长和单链可变片段是为检测、预防和控制寄生虫、细菌和病毒疾病以及治疗疼痛和癌症而开发的最常见的rAb形式。尽管如此，研究进展似乎偏向于经济上重要的动物，如猪、牛、家禽和狗。虽然本文报道的rAb已取得显著成果，但大多数尚未充分开发到可获批的程度。应鼓励进一步的研究和临床试验，以使重要发现能够充分发挥其改善动物健康的预期潜力。
