恶病质素与肿瘤坏死因子是同一枚生物硬币的两面。
Cachectin and tumour necrosis factor as two sides of the same biological coin.
作者信息
Beutler B, Cerami A
出版信息
Nature. 1986;320(6063):584-8. doi: 10.1038/320584a0.
DOI:10.1038/320584a0
PMID:3010124
Abstract
In response to invasive stimuli macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.
摘要
巨噬细胞在受到侵袭性刺激时会分泌恶病质素，这是一种具有多种功能的蛋白质。其显著的生物学效应包括能够诱发消瘦（恶病质）以及导致致命的休克状态。恶病质素与肿瘤坏死因子的一致性引发了对其治疗潜力的新看法。
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