Lee Seul, Kang Bo Hyoung, Ryu Won Yeol, Um Soo Jung, Roh Mee Sook, Son Choonhee
Division of Pulmonology, Department of Internal Medicine, College of Medicine, Dong-A University, Korea.
Department of Ophthalmology, College of Medicine, Dong-A University, Korea.
Intern Med. 2018 Dec 15;57(24):3611-3613. doi: 10.2169/internalmedicine.1344-18. Epub 2018 Aug 10.
Linezolid is a useful drug for treating drug-resistant tuberculosis. However, the associated toxicities, especially optic neuritis, are a major obstacle for its long-term use. We recently experienced a case of severe optic and peripheral neuropathy during the treatment of multidrug-resistant tuberculosis. The treatment continued for 12 months despite severe optic and peripheral neuropathy. At eight months after the discontinuation of the drug, the optic neuropathy recovered, but the peripheral neuropathy did not. Considering the grave prognosis of drug-resistant tuberculosis, the continuation of linezolid despite neurotoxicity under close observation may be a suitable option.
利奈唑胺是治疗耐药结核病的一种有效药物。然而，其相关毒性，尤其是视神经炎，是其长期使用的主要障碍。我们最近遇到了一例在治疗耐多药结核病期间发生严重视神经和周围神经病变的病例。尽管出现了严重的视神经和周围神经病变，治疗仍持续了12个月。停药8个月后，视神经病变恢复，但周围神经病变未恢复。考虑到耐药结核病的严重预后，在密切观察下尽管存在神经毒性仍继续使用利奈唑胺可能是一个合适的选择。
