Karuppannasamy Divya, Raghuram Andavar, Sundar Devisundaram
Department of Ophthalmology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
Indian J Ophthalmol. 2014 Apr;62(4):497-500. doi: 10.4103/0301-4738.118451.
Many systemic antimicrobials have been implicated to cause ocular adverse effects. This is especially relevant in multidrug therapy where more than one drug can cause a similar ocular adverse effect. We describe a case of progressive loss of vision associated with linezolid therapy. A 45-year-old male patient who was on treatment with multiple second-line anti-tuberculous drugs including linezolid and ethambutol for extensively drug-resistant tuberculosis (XDR-TB) presented to us with painless progressive loss of vision in both eyes. Color vision was defective and fundus examination revealed optic disc edema in both eyes. Ethambutol-induced toxic optic neuropathy was suspected and tablet ethambutol was withdrawn. Deterioration of vision occurred despite withdrawal of ethambutol. Discontinuation of linezolid resulted in marked improvement of vision. Our report emphasizes the need for monitoring of visual function in patients on long-term linezolid treatment.
许多全身性抗菌药物都被认为会引起眼部不良反应。这在多药治疗中尤为相关，因为不止一种药物可能会导致类似的眼部不良反应。我们描述了一例与利奈唑胺治疗相关的进行性视力丧失病例。一名45岁男性患者因广泛耐药结核病（XDR-TB）正在接受包括利奈唑胺和乙胺丁醇在内的多种二线抗结核药物治疗，他前来就诊时双眼出现无痛性进行性视力丧失。色觉有缺陷，眼底检查显示双眼视盘水肿。怀疑是乙胺丁醇引起的中毒性视神经病变，遂停用乙胺丁醇片。尽管停用了乙胺丁醇，视力仍继续恶化。停用利奈唑胺后视力显著改善。我们的报告强调了对长期接受利奈唑胺治疗的患者进行视觉功能监测的必要性。
