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膳食补充不可消化低聚糖可减轻过敏症状并支持低剂量口服免疫治疗花生过敏小鼠模型。

Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model.

机构信息

Department of Immunotoxicology, Institute for Risk Assessment Sciences, Utrecht University, Yalelaan 104, NL-3584 CM, Utrecht, The Netherlands.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, NL-3584 CG, Utrecht, The Netherlands.

出版信息

Mol Nutr Food Res. 2018 Oct;62(20):e1800369. doi: 10.1002/mnfr.201800369. Epub 2018 Aug 31.

DOI:10.1002/mnfr.201800369
PMID:30102006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6766954/
Abstract

SCOPE

A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non-digestible short- and long-chain fructo-oligosaccharides (scFOS/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS/lcFOS can also support the efficacy of OIT in a peanut allergy model.

METHODS AND RESULTS

After sensitization to peanut extract (PE) using cholera toxin, C3H/HeOuJ mice are fed a 1% scFOS/lcFOS or control diet and receive OIT (1.5 or 15 mg PE). Hereafter, mice are exposed to PE via different routes to determine the safety and efficacy of treatment in clinical outcomes, PE-specific antibody production, and numbers of various immune cells. scFOS/lcFOS increases short-chain fatty acid levels in the caecum and reduce the acute allergic skin response and drop in body temperature after PE exposure. Interestingly, 15 mg and 1.5 mg OIT with scFOS/lcFOS induce protection against anaphylaxis, whereas 1.5 mg OIT alone does not. OIT, with or without scFOS/lcFOS, induces PE-specific immunoglobulin (Ig) IgG and IgA levels and increases CD103+ dendritic cells in the mesenteric lymph nodes.

CONCLUSIONS

scFOS/lcFOS and scFOS/lcFOS combined with low dose OIT are able to protect against a peanut-allergic anaphylactic response.

摘要

范围

口服免疫疗法（OIT）治疗食物过敏的一个主要缺点是存在严重副作用的风险。不可消化的短链和长链果糖低聚糖（scFOS/lcFOS）可减少小鼠模型中的过敏发展。因此，据推测 scFOS/lcFOS 也可以支持花生过敏模型中 OIT 的疗效。

方法和结果

使用霍乱毒素对花生提取物（PE）进行致敏后，C3H/HeOuJ 小鼠喂食 1%的 scFOS/lcFOS 或对照饮食，并接受 OIT（1.5 或 15 mg PE）。此后，通过不同途径使小鼠暴露于 PE，以确定治疗在临床结局、PE 特异性抗体产生和各种免疫细胞数量方面的安全性和疗效。scFOS/lcFOS 增加了盲肠中的短链脂肪酸水平，并减少了 PE 暴露后的急性过敏皮肤反应和体温下降。有趣的是，15 mg 和 1.5 mg OIT 与 scFOS/lcFOS 联合使用可诱导对过敏反应的保护，而单独使用 1.5 mg OIT 则不行。OIT，无论是否与 scFOS/lcFOS 联合使用，均可诱导 PE 特异性免疫球蛋白（Ig）IgG 和 IgA 水平，并增加肠系膜淋巴结中的 CD103+树突状细胞。

结论

scFOS/lcFOS 和低剂量 OIT 联合使用能够预防花生过敏的过敏反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f7/6766954/c32491e554ed/MNFR-62-na-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f7/6766954/72a51348ffde/MNFR-62-na-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f7/6766954/34000a239b3a/MNFR-62-na-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f7/6766954/5bad75902488/MNFR-62-na-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f7/6766954/98cc5f841c37/MNFR-62-na-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f7/6766954/c32491e554ed/MNFR-62-na-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f7/6766954/72a51348ffde/MNFR-62-na-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f7/6766954/34000a239b3a/MNFR-62-na-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f7/6766954/5bad75902488/MNFR-62-na-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f7/6766954/98cc5f841c37/MNFR-62-na-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8f7/6766954/c32491e554ed/MNFR-62-na-g005.jpg

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Front Immunol. 2017 Sep 29;8:1230. doi: 10.3389/fimmu.2017.01230. eCollection 2017.
2
The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models.口服和皮下抗原特异性免疫疗法在小鼠牛奶和花生过敏模型中的疗效。
Clin Transl Allergy. 2017 Sep 29;7:35. doi: 10.1186/s13601-017-0170-y. eCollection 2017.
3
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作为食物过敏中肥大细胞功能抑制剂的变应原特异性 IgA 和 IgG 抗体。
Front Allergy. 2024 Jun 11;5:1389669. doi: 10.3389/falgy.2024.1389669. eCollection 2024.
4
Low-dose oral immunotherapy in immunoglobulin E-mediated food allergies.低剂量口服免疫疗法治疗免疫球蛋白 E 介导的食物过敏。
Front Immunol. 2024 Feb 1;15:1321863. doi: 10.3389/fimmu.2024.1321863. eCollection 2024.
5
Preclinical evaluation of alternatives to oral immunotherapy for food allergies.食物过敏口服免疫疗法替代方案的临床前评估。
Front Allergy. 2023 Oct 3;4:1275373. doi: 10.3389/falgy.2023.1275373. eCollection 2023.
6
Effect of Xylo-Oligosaccharides Supplementation by Drinking Water on the Bone Properties and Related Calcium Transporters in Growing Mice.饮水补充木低聚糖对生长小鼠骨特性和相关钙转运体的影响。
Nutrients. 2020 Nov 19;12(11):3542. doi: 10.3390/nu12113542.
7
A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment.天然生物活性化合物和益生菌作为食物过敏治疗中潜在疗法的全面综述。
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8
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9
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J Allergy Clin Immunol. 2017 Jan;139(1):173-181.e8. doi: 10.1016/j.jaci.2016.05.027. Epub 2016 Aug 10.
6
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7
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8
Improving the safety of oral immunotherapy for food allergy.提高食物过敏口服免疫疗法的安全性。
Pediatr Allergy Immunol. 2016 Mar;27(2):117-25. doi: 10.1111/pai.12510. Epub 2015 Dec 22.
9
Oral Immunotherapy for Peanut Allergy.口服免疫疗法治疗花生过敏
Annu Rev Med. 2016;67:375-85. doi: 10.1146/annurev-med-061014-094943. Epub 2015 Aug 26.
10
Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants.关于在高危婴儿中早期引入花生和预防花生过敏的共识沟通。
J Allergy Clin Immunol. 2015 Aug;136(2):258-61. doi: 10.1016/j.jaci.2015.06.001. Epub 2015 Jun 20.