Institute for Translational Medicine, Qingdao University, Qingdao, China.
The Affiliated Hospital of Qingdao University, Qingdao, China.
J Cell Mol Med. 2018 Oct;22(10):4558-4567. doi: 10.1111/jcmm.13669. Epub 2018 Aug 13.
Ubiquitination, also known as ubiquitylation, is a vital post-translational modification of proteins that play a crucial role in the multiple biological processes including cell growth, proliferation and apoptosis. K63-linked ubiquitination is one of the vital post-translational modifications of proteins that are involved in the activation of protein kinases and protein trafficking during cell survival and proliferation. It also contributes to the development of various disorders including cancer, neurodegeneration and cardiac hypertrophy. In this review, we summarize the role of K63-linked ubiquitination signalling in protein kinase activation and its implications in cardiac hypertrophy. We have also provided our perspectives on therapeutically targeting K63-linked ubiquitination in downstream effector molecules of growth factor receptors for the treatment of cardiac hypertrophy.
泛素化，也称为泛素化，是蛋白质的一种重要的翻译后修饰，在包括细胞生长、增殖和凋亡在内的多种生物过程中发挥着关键作用。K63 连接的泛素化是蛋白质的一种重要的翻译后修饰，参与了细胞存活和增殖过程中蛋白激酶的激活和蛋白运输。它还导致了包括癌症、神经退行性疾病和心肌肥厚在内的多种疾病的发生。在这篇综述中，我们总结了 K63 连接的泛素化信号在蛋白激酶激活中的作用及其在心肌肥厚中的意义。我们还就针对生长因子受体下游效应分子的 K63 连接泛素化在治疗心肌肥厚方面的治疗靶点提出了我们的看法。
