Tong Qiaowen, Xiang Weiwei, Ye Hua, Zhang Hehui, Chen Yiyi, Chen Weian, Liu Chunfeng
a Department of Neurology , The Second Affiliated Hospital of Soochow University , Suzhou , China.
b Department of Neurology , Wenzhou People's Hospital , Wenzhou , China.
Int J Neurosci. 2019 Feb;129(2):139-145. doi: 10.1080/00207454.2018.1510833. Epub 2018 Oct 31.
Acute central nervous system viral infections are progressive and inflammatory diseases with inflammatory cells infiltrating into the central nervous system (CNS), and thyroid hormone (TH) level is associated with the oxidative and antioxidant status. Variations in oxidative stress and antioxidant status are related to the pathogenesis of inflammatory diseases. Our study aimed to investigate the possible correlation between viral infections in CNS and TH levels of thyroid stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3).
We measured serum concentrations of TSH, fT4, and fT3 in 206 individuals, including 59 viral meningitis (VM) patients, 60 viral encephalitis (VE) patients, and 87 healthy controls.
Our findings showed that VE and VM patients had lower levels of fT3 and higher levels of fT4 compared with healthy controls, whether male or female. Moreover, levels of TSH and fT3 in patients with viral infections in CNS were inversely correlated with disease prognosis measured by the Glasgow Outcome Scale.
Variations in TH level may represent the oxidative status and are surrogate biomarkers for disease prognosis of acute central nervous system viral infections.
急性中枢神经系统病毒感染是一种进展性炎症性疾病，炎症细胞浸润中枢神经系统（CNS），甲状腺激素（TH）水平与氧化及抗氧化状态相关。氧化应激和抗氧化状态的变化与炎症性疾病的发病机制有关。我们的研究旨在探讨中枢神经系统病毒感染与甲状腺刺激激素（TSH）、游离甲状腺素（fT4）和游离三碘甲状腺原氨酸（fT3）的TH水平之间可能存在的相关性。
我们测定了206例个体的血清TSH、fT4和fT3浓度，其中包括59例病毒性脑膜炎（VM）患者、60例病毒性脑炎（VE）患者和87例健康对照者。
我们的研究结果表明，无论男性还是女性，与健康对照者相比，VE和VM患者的fT3水平较低，fT4水平较高。此外，中枢神经系统病毒感染患者的TSH和fT3水平与通过格拉斯哥预后量表测量的疾病预后呈负相关。
TH水平的变化可能代表氧化状态，是急性中枢神经系统病毒感染疾病预后的替代生物标志物。
