Department of Head and Neck Oncology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Tamilnadu, India.
Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Camperdown, New South Wales, Australia.
Head Neck. 2018 Oct;40(10):2123-2128. doi: 10.1002/hed.25168. Epub 2018 Aug 13.
The American Joint Committee on Cancer (AJCC) eighth edition has incorporated depth of invasion into TNM classification of oral cavity squamous cell carcinoma (SCC) due to the prognostic impact on recurrence and survival. After reclassifying our patients with T1 to T2 oral cavity SCC according to these recommendations, we intended to study the effect of adverse pathological features (perineural invasion [PNI], lymphovascular invasion, and differentiation) on overall survival (OS).
We conducted a retrospective analysis of 442 patients with T1 to T2 oral cavity SCC. Univariate and multivariate analysis was performed for impact of adverse pathological features on OS.
For the newly reclassified T1 to T2 oral cavity tumors, on multivariate analysis, the prognostically relevant parameters were PNI (P = .032) and differentiation (P = .009). Increasing adverse pathological features resulted in worse survival (P = .005).
Incorporation of PNI and differentiation better reflect prognostic outcome in oral cavity tumors classified as T1 to T2 as per the new AJCC eighth edition. Increasing adverse pathological features resulted in worse survival.
由于深度浸润对口腔鳞状细胞癌（SCC）的复发和生存有预后影响，美国癌症联合委员会（AJCC）第八版将其纳入了 TNM 分类。根据这些建议重新分类 T1 至 T2 期口腔 SCC 患者后，我们旨在研究不良病理特征（神经周围侵犯[PNI]、血管淋巴管侵犯和分化）对总生存（OS）的影响。
我们对 442 例 T1 至 T2 期口腔 SCC 患者进行了回顾性分析。对不良病理特征对 OS 的影响进行了单因素和多因素分析。
对于新分类的 T1 至 T2 期口腔肿瘤，多因素分析显示，PNI（P =.032）和分化（P =.009）是预后相关的参数。不良病理特征的增加导致生存率下降（P =.005）。
根据 AJCC 第八版，PNI 和分化的纳入更好地反映了 T1 至 T2 期口腔肿瘤的预后结果。不良病理特征的增加导致生存率下降。
