Innovation Center for Neurological Disorders, Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China.
Department of Neurology, Duke University School of Medicine, Durham, NC, USA.
Alzheimers Dement. 2019 Jan;15(1):168-171. doi: 10.1016/j.jalz.2018.06.3058. Epub 2018 Aug 10.
The new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease has been developed to accelerate drug discovery and offer a common structure and language to construct new Alzheimer's disease conceptual models. However, as a "complex" disease, a model based on systems-level understanding is needed to accommodate the complex, interacting etiologic pathways and the system-level changes associated with Alzheimer's disease pathogenesis and interventions that are currently known and which will be identified in the future. To accomplish this, the evolution of the structure of the research framework itself should be encouraged.
新的美国国家老龄化研究所和阿尔茨海默病协会的阿尔茨海默病研究框架旨在加速药物发现，并提供一个共同的结构和语言来构建新的阿尔茨海默病概念模型。然而，作为一种“复杂”疾病，需要基于系统水平理解的模型来适应复杂的、相互作用的病因途径，以及与阿尔茨海默病发病机制和干预措施相关的系统水平变化，这些变化目前已经被认识到，并且在未来还将被发现。为了实现这一目标，应该鼓励研究框架本身的结构演变。
