Soliman K F, Mash D C, Walker C A
Proc Soc Exp Biol Med. 1986 Jun;182(2):187-93. doi: 10.3181/00379727-182-42326.
The purpose of the present study was to examine the effect of altering the concentration of 5-hydroxytryptamine (5-HT) on beta-endorphin (beta-Ep) content in the hypothalamus, thalamus, and periaqueductal gray (PAG)-rostral pons regions of the rat brain. The selective 5-HT reuptake inhibitor, fluoxetine (10 mg/kg), significantly lowered beta-Ep content in the hypothalamus and the PAG. Parachlorophenylalanine, which inhibits 5-HT synthesis, significantly elevated beta-Ep in all brain parts studied. Intracisternal injections of the neurotoxin, 5',7'-dihydroxytryptamine, with desmethylimipramine pretreatment, significantly increased beta-Ep content in the hypothalamus and the PAG. In adrenalectomized rats, fluoxetine significantly decreased beta-Ep levels in the hypothalamus and increased the levels in the PAG. The results indicate that 5-HT may modulate the levels of brain beta-Ep.
本研究的目的是检测改变5-羟色胺（5-HT）浓度对大鼠脑下丘脑、丘脑及导水管周围灰质-延髓头端区域中β-内啡肽（β-Ep）含量的影响。选择性5-HT再摄取抑制剂氟西汀（10毫克/千克）显著降低了下丘脑和导水管周围灰质中的β-Ep含量。抑制5-HT合成的对氯苯丙氨酸显著提高了所有研究脑区中的β-Ep含量。经去甲丙咪嗪预处理后，脑池内注射神经毒素5'，7'-二羟基色胺，显著增加了下丘脑和导水管周围灰质中的β-Ep含量。在肾上腺切除的大鼠中，氟西汀显著降低了下丘脑的β-Ep水平，提高了导水管周围灰质中的β-Ep水平。结果表明，5-HT可能调节脑内β-Ep水平。
