Zarei Adi Essam, Redwan Elrashdy M
Biological Sciences Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Main Medical Laboratory, Medical Services, Saudi Airlines, Jeddah 21231, Saudi Arabia.
Hum Antibodies. 2019;27(1):13-22. doi: 10.3233/HAB-180345.
Our previous results showed higher level of anti-Hib IgG (2.41 μg/ml) average geometric mean concentration (GMC) regardless of age and gender, followed by levels of IgM (0.91 μg/ml) and IgA (0.34 μg/ml), reflecting the prevalence of immunity against Hib. Current study was evaluated the avidity profile for these high anti-Hib concentration. The IgM avidity analysis did not revealed any significant results between male and female values. While, the average of IgA avidity in male samples were significantly (P< 0.05) higher than the average of female. Also, The result showed that high percentage of population has moderate to high IgG avidity. The study showed lower avidity percentages of both IgM and IgA comparing to IgG. More studies are suggested to be done on individuals with low avidity considering the secondary immunodeficiency in participant's history.
我们之前的结果显示，无论年龄和性别，抗B型流感嗜血杆菌IgG的平均几何平均浓度（GMC）水平较高（2.41μg/ml），其次是IgM（0.91μg/ml）和IgA（0.34μg/ml）水平，这反映了对B型流感嗜血杆菌免疫的流行情况。当前研究评估了这些高抗B型流感嗜血杆菌浓度的亲和力特征。IgM亲和力分析未显示男性和女性值之间有任何显著结果。然而，男性样本中IgA亲和力的平均值显著高于女性平均值（P<0.05）。此外，结果表明高比例人群具有中度至高IgG亲和力。该研究显示，与IgG相比，IgM和IgA的低亲和力百分比更低。考虑到参与者病史中的继发性免疫缺陷，建议对低亲和力个体进行更多研究。
