Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
Int J Mol Sci. 2018 Aug 10;19(8):2354. doi: 10.3390/ijms19082354.
Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research.
视黄醇 X 受体 (RXR) 拮抗剂不仅可用作生物学研究的化学工具，而且还是治疗各种疾病（包括糖尿病和过敏）的候选药物，尽管尚未有 RXR 拮抗剂获得临床批准。在这篇综述中，我们简要介绍了 RXR 的结构、功能和靶基因，并描述了目前可用的 RXR 拮抗剂、它们的结构分类及其评估，重点介绍了最新的研究。
