Division of Hepatobiliary and Pancreatic disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
Nutrients. 2018 Aug 12;10(8):1072. doi: 10.3390/nu10081072.
To investigate the relationship between extracellular water to total body water ratio (ECW/TBW) in bioimpedance analysis (BIA) and clinical parameters in hepatitis viruses related to liver diseases.
ECW/TBW was compared in patients with hepatitis B virus (HBV, = 85) and hepatitis C virus (HCV, = 440) related liver diseases. We also examined factors linked to mild to severe overhydrated state (ECW/TBW ≥0.4).
The median ECW/TBW in the HCV group was 0.388 (range, 0.365⁻0.433), while that in the HBV group was 0.381 (range, 0.363⁻0.425) ( < 0.0001). In all cases ( = 525), for predicting F3 or more, ECW/TBW yielded the area under the receiver operating characteristics (AUROC, 0.74912) and for predicting F4, ECW/TBW yielded the AUROC (0.75517). Multivariate analysis showed that age, prothrombin time, serum albumin, and alanine aminotransferase were significant factors linked to ECW/TBW ≥0.4. In patients with FIB-4 index <2, ECW/TBW in the HCV group was significantly higher than that in the HBV group ( = 0.0188), while in patients with 2 ≤ FIB-4 index <4 and FIB-4 index ≥4, the difference in the two groups did not reach significance.
ECW/TBW can be different according to hepatitis viruses. Overhydrated status can easily occur in the HCV group even in the non-LC status compared with the HBV group.
探讨生物电阻抗分析（BIA）中外周组织液与总体水量比值（ECW/TBW）与肝炎病毒相关肝病的临床参数之间的关系。
比较乙型肝炎病毒（HBV，n = 85）和丙型肝炎病毒（HCV，n = 440）相关肝病患者的 ECW/TBW。我们还检查了与轻度至重度水过多状态（ECW/TBW ≥0.4）相关的因素。
HCV 组的 ECW/TBW 中位数为 0.388（范围，0.365⁻0.433），而 HBV 组为 0.381（范围，0.363⁻0.425）（<0.0001）。在所有病例（n = 525）中，对于预测 F3 或更严重程度，ECW/TBW 的受试者工作特征曲线（AUROC，0.74912）下面积和预测 F4，ECW/TBW 的 AUROC（0.75517）。多变量分析显示，年龄、凝血酶原时间、血清白蛋白和丙氨酸氨基转移酶是与 ECW/TBW ≥0.4 相关的重要因素。在 FIB-4 指数<2 的患者中，HCV 组的 ECW/TBW 明显高于 HBV 组（=0.0188），而在 2 ≤ FIB-4 指数<4 和 FIB-4 指数≥4 的患者中，两组之间的差异无统计学意义。
根据肝炎病毒的不同，ECW/TBW 可能会有所不同。与 HBV 组相比，HCV 组即使在非 LC 状态下也容易发生水过多状态。
