应用生物电阻抗分析技术研究病毒性肝病患者细胞外液与总体液比值

Extracellular Water to Total Body Water Ratio in Viral Liver Diseases: A Study Using Bioimpedance Analysis.

机构信息

Division of Hepatobiliary and Pancreatic disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.

出版信息

Nutrients. 2018 Aug 12;10(8):1072. doi: 10.3390/nu10081072.

AIMS

To investigate the relationship between extracellular water to total body water ratio (ECW/TBW) in bioimpedance analysis (BIA) and clinical parameters in hepatitis viruses related to liver diseases.

METHODS

ECW/TBW was compared in patients with hepatitis B virus (HBV, = 85) and hepatitis C virus (HCV, = 440) related liver diseases. We also examined factors linked to mild to severe overhydrated state (ECW/TBW ≥0.4).

RESULTS

The median ECW/TBW in the HCV group was 0.388 (range, 0.365⁻0.433), while that in the HBV group was 0.381 (range, 0.363⁻0.425) ( < 0.0001). In all cases ( = 525), for predicting F3 or more, ECW/TBW yielded the area under the receiver operating characteristics (AUROC, 0.74912) and for predicting F4, ECW/TBW yielded the AUROC (0.75517). Multivariate analysis showed that age, prothrombin time, serum albumin, and alanine aminotransferase were significant factors linked to ECW/TBW ≥0.4. In patients with FIB-4 index <2, ECW/TBW in the HCV group was significantly higher than that in the HBV group ( = 0.0188), while in patients with 2 ≤ FIB-4 index <4 and FIB-4 index ≥4, the difference in the two groups did not reach significance.

CONCLUSION

ECW/TBW can be different according to hepatitis viruses. Overhydrated status can easily occur in the HCV group even in the non-LC status compared with the HBV group.

目的

探讨生物电阻抗分析（BIA）中外周组织液与总体水量比值（ECW/TBW）与肝炎病毒相关肝病的临床参数之间的关系。

方法

比较乙型肝炎病毒（HBV，n = 85）和丙型肝炎病毒（HCV，n = 440）相关肝病患者的 ECW/TBW。我们还检查了与轻度至重度水过多状态（ECW/TBW ≥0.4）相关的因素。

结果

HCV 组的 ECW/TBW 中位数为 0.388（范围，0.365⁻0.433），而 HBV 组为 0.381（范围，0.363⁻0.425）（<0.0001）。在所有病例（n = 525）中，对于预测 F3 或更严重程度，ECW/TBW 的受试者工作特征曲线（AUROC，0.74912）下面积和预测 F4，ECW/TBW 的 AUROC（0.75517）。多变量分析显示，年龄、凝血酶原时间、血清白蛋白和丙氨酸氨基转移酶是与 ECW/TBW ≥0.4 相关的重要因素。在 FIB-4 指数<2 的患者中，HCV 组的 ECW/TBW 明显高于 HBV 组（=0.0188），而在 2 ≤ FIB-4 指数<4 和 FIB-4 指数≥4 的患者中，两组之间的差异无统计学意义。