Bowersox S S, Kilduff T S, Kaitin K I, Dement W C, Ciaranello R D
Sleep. 1986;9(1 Pt 2):111-5. doi: 10.1093/sleep/9.1.111.
A regional analysis of brain benzodiazepine (BDZ) receptors was conducted in narcoleptic and normal dogs to determine whether these sites are altered in narcolepsy. It was postulated that BDZ receptors play a role in the excessive sleepiness of narcolepsy because activation of these sites in freely behaving normal animals is hypnogenic. [3H]Flunitrazepam binding sites were assessed in 11 discrete areas of the forebrain and brainstem. No consistent or statistically significant group differences in either receptor densities (Bmax) or binding affinities (Kd) were found. These findings do not support the assertion that BDZ receptors are involved in the pathogenesis of canine narcolepsy.
对发作性睡病犬和正常犬的脑苯二氮䓬（BDZ）受体进行了区域分析，以确定这些位点在发作性睡病中是否发生改变。据推测，BDZ受体在发作性睡病的过度嗜睡中起作用，因为在自由活动的正常动物中激活这些位点会诱发睡眠。在前脑和脑干的11个离散区域评估了[3H]氟硝西泮结合位点。在受体密度（Bmax）或结合亲和力（Kd）方面未发现一致的或具有统计学意义的组间差异。这些发现不支持BDZ受体参与犬发作性睡病发病机制的观点。
