Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
IET Nanobiotechnol. 2018 Sep;12(6):846-849. doi: 10.1049/iet-nbt.2017.0321.
Developing nanostructures for cancer treatment is growing significantly. Liposomal doxorubicin is a drug that is used in the clinic and represents a lot of benefits over doxorubicin. The development of multifunctional liposomes with different cancer treatment capability enables broader applications of doxorubicin chemotherapy. Many efforts were carried to prepare more effective liposomal formulation through loading gold nanoparticles (GNPs) in the formulation. Here, GNPs with an average size of 6 nm were loaded in liposomal formulation alongside doxorubicin. The hydrodynamic diameter of final formulation was 177.3 ± 33.9 nm that in comparison with liposomes without GNPs (112.5 ± 10.3 nm), GNPs-loaded liposomes showed the bigger hydrodynamic diameter. GNPs-loaded liposomes are slightly positively charged (4.4 ± 1.1 mV), while liposomes without loading the GNPs were negatively charged (-18.5 ± 1.6 mV). Doxorubicin was loaded in this formulation through active loading technique. Doxorubicin loading efficiency in gold-loaded liposomes is slightly lesser than liposomes without GNPs, but still considerably high in comparison to passive loading techniques.
用于癌症治疗的纳米结构的发展正在迅速发展。阿霉素脂质体是一种在临床上使用的药物，与阿霉素相比具有许多优势。通过在制剂中加载金纳米颗粒 (GNPs)，开发具有不同癌症治疗能力的多功能脂质体使阿霉素化疗的应用更加广泛。许多努力都被用来通过制备更有效的脂质体制剂来加载金纳米粒子 (GNPs)。在这里，平均粒径为 6nm 的 GNPs 与阿霉素一起加载在脂质体制剂中。最终制剂的水动力直径为 177.3±33.9nm，与没有 GNPs 的脂质体 (112.5±10.3nm) 相比，GNPs 负载的脂质体显示出更大的水动力直径。GNPs 负载的脂质体带轻微正电荷 (4.4±1.1mV)，而未加载 GNPs 的脂质体带负电荷 (-18.5±1.6mV)。阿霉素通过主动加载技术加载到该制剂中。金负载脂质体中的阿霉素载药效率略低于没有 GNPs 的脂质体，但与被动载药技术相比仍然相当高。
