金纳米颗粒在癌症放射治疗中的放射增敏作用综述。
A review on gold nanoparticles radiosensitization effect in radiation therapy of cancer.
作者信息
Mesbahi Asghar
机构信息
Medical Physics Department, Medical School, Tabriz University of Medical Sciences, Attare-Neishabouri Street, Tabriz, Iran ; Radiation Oncology Department, Imam Hospital, Tabriz, Iran.
出版信息
Rep Pract Oncol Radiother. 2010 Oct 8;15(6):176-80. doi: 10.1016/j.rpor.2010.09.001.
Abstract
In the recent years, application of nanoparticles in diagnosis and treatment of cancer has been the issue of extensive research. Among these studies some have focused on the dose enhancement effect of gold nanoparticles (GNPs) in radiation therapy of cancer. On the other hand, some studies indicated energy dependency of dose enhancement effect, and the others have studied the GNP size effect in association with photon energy. However, in some aspects of GNP-based radiotherapy the results of recent studies do not seem very conclusive in spite of relative agreement on the basic physical interaction of photoelectric between GNPs and low energy photons. The main idea behind the GNP dose enhancement in some studies is not able to explain the results especially in recent investigation on cell lines and animal models radiation therapy using GNPs. In the present article the results of the available reports and articles were analyzed and compared and the final status of the GNP-RT was discussed.
摘要
近年来，纳米粒子在癌症诊断和治疗中的应用一直是广泛研究的课题。在这些研究中，一些聚焦于金纳米粒子（GNPs）在癌症放射治疗中的剂量增强效应。另一方面，一些研究表明剂量增强效应存在能量依赖性，还有一些研究探讨了GNP尺寸效应与光子能量的关系。然而，尽管在GNPs与低能光子之间的光电基本物理相互作用方面有相对一致的观点，但在基于GNP的放射治疗的某些方面，近期研究结果似乎并不十分确凿。一些研究中GNP剂量增强背后的主要观点无法解释这些结果，尤其是在近期关于使用GNPs进行细胞系和动物模型放射治疗的研究中。在本文中，对现有报告和文章的结果进行了分析和比较，并讨论了GNP-RT的最终状况。
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