College of Environmental Science and Engineering, Donghua University, Shanghai 201620, China.
School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China.
Molecules. 2018 Aug 13;23(8):2015. doi: 10.3390/molecules23082015.
The oxidation of cefalexin (CFX), a commonly used cephalosporin antibiotic, was investigated by permanganate (PM) in water. Apparent second-order rate constant of the reaction between CFX and PM was determined to be 12.71 ± (1.62) M·s at neutral pH. Lower pH was favorable for the oxidation of CFX by PM. The presence of Cl and HCO₃ could enhance PM-induced oxidation of CFX, whereas HA had negligible effect on CFX oxidation by PM. PM-induced oxidation of CFX was also significant in the real wastewater matrix. After addition of bisulfite (BS), PM-induced oxidation was significantly accelerated owing to the generation of Mn(III) reactive species. Product analysis indicated oxidation of CFX to three products, with two stereoisomeric sulfoxide products and one di-ketone product. The thioether sulfur and double bond on the six-membered ring were the reactive sites towards PM oxidation. Antibacterial activity assessment indicated that the activity of CFX solution was significantly reduced after PM oxidation.
采用高锰酸盐（PM）在水中对常用头孢菌素类抗生素头孢氨苄（CFX）的氧化作用进行了研究。在中性 pH 下，CFX 与 PM 之间的反应表观二级速率常数确定为 12.71±（1.62）M·s。较低的 pH 有利于 PM 对 CFX 的氧化。Cl 和 HCO₃的存在可以增强 PM 诱导的 CFX 氧化，而 HA 对 PM 氧化 CFX 的影响可以忽略不计。PM 诱导的 CFX 氧化在实际废水基质中也很显著。加入亚硫酸氢盐（BS）后，由于生成了 Mn(III)反应性物质，PM 诱导的氧化明显加速。产物分析表明，CFX 被氧化为三种产物，其中两种立体异构的亚砜产物和一种二酮产物。六元环上的硫醚硫和双键是 PM 氧化的反应位点。抗菌活性评估表明，PM 氧化后 CFX 溶液的活性显著降低。
