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肾移植受者的胆囊病变:单中心经验及文献综述

Gallbladder Pathologies in Kidney Transplant Recipients: Single-Center Experience and a Review of the Literature.

作者信息

Dobosz Łukasz, Kobiela Jarek, Danielewicz Roman, Śledziński Zbigniew, Dębska-Ślizień Alicja

机构信息

Department of General, Endocrine and Transplant Surgery, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.

Department of Surgical and Transplant Nursing, Medical University of Warsaw, Warsaw, Poland.

出版信息

Ann Transplant. 2018 Aug 14;23:572-576. doi: 10.12659/AOT.909653.

DOI:10.12659/AOT.909653
PMID:30104561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6248059/
Abstract

BACKGROUND In patients with end-stage renal disease, cholelithiasis is observed with an increased frequency. In transplant recipients, symptoms might be obscured, which may delay the diagnosis and lead to complications. The aim of our study was to evaluate the frequency of gallbladder pathologies in kidney transplant recipients (KTRs) in the Caucasian population, and to discuss the potential benefits of prophylactic cholecystectomy before kidney transplantation (KT). MATERIAL AND METHODS Data from 434 patients who underwent KT was analyzed. Demographic data along with gallbladder status were collected from the pre-transplantation charts. We compared our results to data from the general Polish population. RESULTS In our analyzed group of KTRs, there were 284 men and 150 women. Complete data, including abdominal ultrasound description, were available in 412 cases. In this group, 36 patients (8.74%) underwent cholecystectomy before KT. Other gallbladder pathologies (gallstones and polyps) were found in 41 patients (9.95%) at pre-transplantation evaluation. The incidence of gallbladder pathologies in KTRs, being mostly cholelithiasis, was higher than in the general Polish population. CONCLUSIONS In specific age subgroups of KTRs, the frequency of gallbladder pathologies was higher than in the general population. Prophylactic cholecystectomy may potentially offer benefits in these subgroups of patients.

摘要

背景

在终末期肾病患者中,胆石症的发生率较高。在肾移植受者中,症状可能不明显,这可能会延迟诊断并导致并发症。我们研究的目的是评估高加索人群中肾移植受者(KTR)胆囊病变的发生率,并探讨肾移植(KT)前预防性胆囊切除术的潜在益处。

材料与方法

分析了434例接受KT患者的数据。从移植前病历中收集人口统计学数据以及胆囊状况。我们将结果与波兰普通人群的数据进行了比较。

结果

在我们分析的KTR组中,有284名男性和150名女性。412例患者有完整数据,包括腹部超声描述。在该组中,36例患者(8.74%)在KT前接受了胆囊切除术。在移植前评估中,41例患者(9.95%)发现有其他胆囊病变(胆结石和息肉)。KTR中胆囊病变的发生率,主要是胆石症,高于波兰普通人群。

结论

在特定年龄亚组的KTR中,胆囊病变的发生率高于普通人群。预防性胆囊切除术可能对这些亚组患者有益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/732d/6248059/900e210e5ef1/anntransplant-23-572-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/732d/6248059/900e210e5ef1/anntransplant-23-572-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/732d/6248059/900e210e5ef1/anntransplant-23-572-g001.jpg

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Gallbladder Pathologies in Kidney Transplant Recipients: Single-Center Experience and a Review of the Literature.肾移植受者的胆囊病变:单中心经验及文献综述
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Immunosuppressants and new onset gallstone disease in patients having undergone renal transplantation.肾移植患者使用免疫抑制剂与新发胆结石疾病
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The risk of gallbladder stone formation is increased in patients with predialysis chronic kidney disease but not those undergoing chronic hemodialysis therapy.透析前慢性肾脏病患者发生胆囊结石的风险增加,但接受慢性血液透析治疗的患者则不然。
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