Wang Qingwen, Zhang Xiankai, Xiao Tingting, Pan Chenhua, Liu Xing, Zhao Yulan
Department of Physiology, School of Life Sciences, East China Normal University, Shanghai, People's Republic of China,
Department of Botany, School of Life Sciences, Shanghai Normal University, Shanghai, People's Republic of China.
Ther Clin Risk Manag. 2018 Jul 30;14:1323-1330. doi: 10.2147/TCRM.S171341. eCollection 2018.
Recent studies have shown that Toll-like receptors (TLRs) may be associated with cancers. The aim of this meta-analysis is to summarize the predicting role of TLRs for survival in patients with a variety of carcinomas.
Eligible studies were identified and assessed for quality through multiple search strategies. We collected data from studies investigating the relationship between the expression level of TLRs and survival in cancer patients. Studies were pooled and combined hazard ratios (HRs) of TLRs for survival were analyzed.
A total of 24 studies, including 2,812 patients with various cancers, were identified for the meta-analysis. Importantly, this meta-analysis showed that higher expression levels of TLR4 or TLR7 in tumor tissues could predict poorer survival, with the pooled HR being 1.29 (95% CI: 1.17, 1.42) and 1.71 (95% CI: 1.38, 2.12), respectively. However, higher expression of TLR9 had no significant association with outcome as HR was 0.84 (95% CI: 0.62, 1.115). Heterogeneity existed in TLR4 and TLR9 studies (-value <0.001) but not in TLR7 studies (-value >0.05).
The expression level of TLR4 or TLR7 in cancerous tissue may have a prognosis value in patients with various cancers.
最近的研究表明，Toll样受体（TLRs）可能与癌症有关。本荟萃分析的目的是总结TLRs对各种癌症患者生存的预测作用。
通过多种检索策略识别并评估符合条件的研究的质量。我们收集了研究TLRs表达水平与癌症患者生存之间关系的研究数据。对研究进行汇总，并分析TLRs生存的合并风险比（HRs）。
共纳入24项研究，包括2812例患有各种癌症的患者进行荟萃分析。重要的是，该荟萃分析表明，肿瘤组织中TLR4或TLR7的较高表达水平可预测较差的生存，合并HR分别为1.29（95%CI：1.17，1.42）和1.71（95%CI：1.38，2.12）。然而，TLR9的较高表达与预后无显著关联，HR为0.84（95%CI：0.62，1.115）。TLR4和TLR9研究中存在异质性（P值<0.001），但TLR7研究中不存在异质性（P值>0.05）。
癌组织中TLR4或TLR7的表达水平可能对各种癌症患者具有预后价值。
