Tueche Alain Brice, Zingue Stephane, Tchoupang Edwige Nana, Gueyo Telesphore Nanbo, Gbaweng Yaya Abel Joël, Njuh Amstrong Nang, Ntsa Dieudonnée Mireille, Njamen Dieudonné
Department of Biological Sciences, Faculty of Science, University of Maroua, P.O. Box 814, Maroua, Cameroon.
Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon.
Evid Based Complement Alternat Med. 2018 Jul 11;2018:7959068. doi: 10.1155/2018/7959068. eCollection 2018.
There is a long standing interest in the identification of medicinal plants and derived natural products for developing cancer therapeutics. The present study was designed to evaluate the and antiproliferative effects of Abyssinone V-4' methyl ether (AVME) on breast tissue of mice. The cytotoxicity of AVME was evaluated using MTT assay in four cancer cell lines (DU145, PC3, HepG2, and MCF-7). Further, a protective effect of AVME was evaluated on 7,12-dimethylbenz(a)anthracene- (DMBA-) induced breast tumor in Swiss mice. Incidence, burden, volume, and histological analysis of mammary tumors were measured. As a result, AVME inhibits DU145, PC3, HepG2, and MCF-7 cells growth. , no tumor was detected in mice from the normal group as compared to those of DMBA group. Moreover, AVME inhibits the DMBA-induced mammary glands hyperplasia in mice at the dose of 10 mg/kg, evidenced by a decrease of tumor incidence, tumor weight, and volume as well as a protective effect against the lobular alveolar hyperplasia. Taken all together, these results suggest that Abyssinone V-4' methyl ether is endowed with antitumor properties and could be a source of traditional medicine which deserves to be more elucidated and explored in the foreseeable future.
长期以来，人们一直对鉴定用于开发癌症治疗药物的药用植物和天然产物提取物感兴趣。本研究旨在评估阿比西酮V - 4' - 甲醚（AVME）对小鼠乳腺组织的抗增殖作用。使用MTT法在四种癌细胞系（DU145、PC3、HepG2和MCF - 7）中评估AVME的细胞毒性。此外，评估了AVME对瑞士小鼠中7,12 - 二甲基苯并(a)蒽（DMBA）诱导的乳腺肿瘤的保护作用。测量了乳腺肿瘤的发病率、负荷、体积和组织学分析。结果，AVME抑制DU145、PC3、HepG2和MCF - 7细胞的生长。与DMBA组相比，正常组小鼠未检测到肿瘤。此外，AVME以10 mg/kg的剂量抑制小鼠中DMBA诱导的乳腺增生，表现为肿瘤发病率、肿瘤重量和体积的降低以及对小叶腺泡增生的保护作用。综上所述，这些结果表明阿比西酮V - 4' - 甲醚具有抗肿瘤特性，并且可能是一种传统药物来源，在可预见的未来值得进一步阐明和探索。
