Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Department of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Biomed Res Int. 2018 Jul 19;2018:8345893. doi: 10.1155/2018/8345893. eCollection 2018.
Recently, P16 expression has been shown to be correlated with cancer-specific survival (CSS) in penile squamous cell carcinoma (SCC). Therefore, we performed this meta-analysis to clarify the prognostic value of P16 for penile SCC.
A systematic search was performed in PubMed, Embase, and Web of Science to identify all relevant articles up to May 25, 2017. Hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of included studies were pooled to estimate the prognostic value. Trial sequential analysis (TSA) was performed to assess the quantity and strength of survival evidence.
Five retrospective studies consisting of 323 cases were finally included. We found that P16 positive expression was significantly associated with a better CSS of penile SCC (HR=0.45, 95%CI: 0.30-0.67, P<0.001). No heterogeneity or publication bias was noted among the included studies. Furthermore, TSA demonstrated that the findings were based on sufficient evidence.
P16 positive expression is independently associated with improved CSS for patients with penile SCC.
最近，P16 表达与阴茎鳞癌（SCC）的癌症特异性生存（CSS）相关。因此，我们进行了这项荟萃分析，以阐明 P16 对阴茎 SCC 的预后价值。
系统检索了 PubMed、Embase 和 Web of Science 数据库，以确定截至 2017 年 5 月 25 日的所有相关文献。合并纳入研究的风险比（HR）及其相应的 95%置信区间（CI），以评估预后价值。进行试验序贯分析（TSA）以评估生存证据的数量和强度。
最终纳入了 5 项回顾性研究，共 323 例。我们发现 P16 阳性表达与阴茎 SCC 的 CSS 显著相关（HR=0.45，95%CI：0.30-0.67，P<0.001）。纳入研究之间无异质性或发表偏倚。此外，TSA 表明该研究结果基于充分的证据。
P16 阳性表达与阴茎 SCC 患者的 CSS 改善独立相关。
