Morgan R T, Quinn L A, Woods L K, Moore G E
Cancer Res. 1977 Jul;37(7 Pt 1):2030-5.
A squamous cell carcinoma tumor cell line, COLO 227, derived from a metastatic tumor in a Caucasian male, produces both parathyroid hormone and carcinoembryonic antigen. A chromosome mode of 106 predominated and the X and Y chromosomes were retained. Seven marker chromosomes were identified. Cytogenetic analysis revealed an isochromosome 8 marker similar to a HeLa cell line marker and an isochromosome 17 marker described in other cancers. An autochthonous lymphoid cell line, COLO 219, was established and characterized. COLO 219 is a normal lymphoid cell line with B-cell characteristics. This autochthonous system of both cultured tumor cells and cultured lymphocytes is of use in immunological studies.
一种鳞状细胞癌肿瘤细胞系COLO 227，源自一名高加索男性的转移性肿瘤，可产生甲状旁腺激素和癌胚抗原。其染色体模式以106为主，X和Y染色体得以保留。共鉴定出7条标记染色体。细胞遗传学分析显示，一条8号等臂染色体标记与一种海拉细胞系标记相似，还有一条17号等臂染色体标记在其他癌症中也有描述。一种自体淋巴样细胞系COLO 219被建立并进行了特征描述。COLO 219是一种具有B细胞特征的正常淋巴样细胞系。这种培养的肿瘤细胞和培养的淋巴细胞的自体系统可用于免疫学研究。
