Martin H, Schmidt D
Zentralbl Allg Pathol. 1985;130(6):451-62.
A total of 91 fibrillar, protoplasmic and gemistocytic astrocytomas, 56 pilocytic astrocytomas and 70 glioblastomas, surgically obtained from 1973 to 1979, were evaluated. A four-grade malignancy system was applied to the astrocytomas. The grading criteria for the astrocytomas included quantitative cell density, cellular and nuclear polymorphism, mitotic activity, proliferative changes in the vascular elements and degree of necrosis. Using these criteria it was possible to distinguish four grades. Astrocytoma grades 1 and 2 correspond to the rubric "low-grade astrocytoma" in the English nomenclature, grades 3 and 4 to "high-grade astrocytoma". From the 91 fibrillar, protoplasmic and gemistocytic astrocytomas there were 12, 29, 31 and 19 tumors in grades 1 to 4 respectively. The corresponding distribution for the 56 pilocytic astrocytomas was 20, 29, 6, 1. Median survival for the fibrillar, protoplasmic and gemistocytic group for malignancy grades 1-4 were 43.8, 33.5, 8.4 and 5.6 months respectively. The corresponding figures for the pilocytic astrocytomas grades 1-3 were greater than 66, greater than 69, and 20.0 months.
对1973年至1979年间手术获取的91例纤维型、原浆型和肥胖型星形细胞瘤、56例毛细胞型星形细胞瘤以及70例胶质母细胞瘤进行了评估。对星形细胞瘤采用四级恶性程度系统。星形细胞瘤的分级标准包括细胞数量密度、细胞和核的多形性、有丝分裂活性、血管成分的增殖变化以及坏死程度。使用这些标准能够区分出四个等级。星形细胞瘤1级和2级对应英文命名中的“低级别星形细胞瘤”，3级和4级对应“高级别星形细胞瘤”。在91例纤维型、原浆型和肥胖型星形细胞瘤中，1至4级分别有12例、29例、31例和19例肿瘤。56例毛细胞型星形细胞瘤的相应分布为20例、29例、6例、1例。纤维型、原浆型和肥胖型星形细胞瘤1至4级恶性程度组的中位生存期分别为43.8个月、33.5个月、8.4个月和5.6个月。毛细胞型星形细胞瘤1至3级的相应数字分别大于66个月、大于69个月和20.0个月。
