喹硫平成功治疗齿状核红核苍白球路易体萎缩所致精神病：一例报告
Successful treatment of psychosis in dentatorubral-pallidoluysian atrophy with quetiapine: A case report.
作者信息
Narita Zui, Sumiyoshi Tomiki
机构信息
Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
出版信息
Neuropsychopharmacol Rep. 2018 Mar;38(1):44-46. doi: 10.1002/npr2.12005. Epub 2018 Feb 5.
INTRODUCTION
Patients with dentatorubral-pallidoluysian atrophy (DRPLA) sometimes elicit psychosis. First-generation antipsychotic drugs have been reported to be effective in treating psychotic symptoms associated with the disease. However, little information is available on the benefits of second-generation antipsychotic drugs (SGAs).
CASE
We report on a 47-year-old man with DRPLA whose psychotic symptoms were effectively treated with quetiapine, one of the SGAs. He suffered from delusions, auditory hallucinations, and disorganized speech. Initially, other antipsychotic drugs were tried, but were withdrawn because of adverse effects before switching to quetiapine.
CONCLUSION
Our observations add to the notion that some of the SGAs are useful for ameliorating psychosis in DRPLA.
引言
齿状核红核苍白球路易体萎缩症（DRPLA）患者有时会引发精神病。据报道，第一代抗精神病药物在治疗与该疾病相关的精神病症状方面有效。然而，关于第二代抗精神病药物（SGA）的益处的信息却很少。
病例
我们报告了一名47岁的DRPLA男性患者，其精神病症状通过SGA之一的喹硫平得到有效治疗。他患有妄想、幻听和言语紊乱。最初尝试了其他抗精神病药物，但在改用喹硫平之前因不良反应而停药。
结论
我们的观察结果进一步证明，某些SGA有助于改善DRPLA患者的精神病症状。
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