Okafor M C, Oduleye S O
Acta Physiol Hung. 1986;67(1):45-51.
The haemodynamic responses of the isolated, perfused gill of the tropical cichlid, Oreochromas (Sarotherodon) niloticus, to exogenous application of adenosine and adenosine triphosphate (ATP) showed that both drugs are potent vasoactive agents. However, while adenosine had vasoconstrictory effect, ATP induced vasodilation. ATP-induced vasodilation was reversibily inhibited in the presence of the enzyme, adenosine deaminase, and the P1 receptor antagonist, theophylline, but was unaffected by the P2 receptor antagonist, quinidine. This indicates that ATP acts specifically through P1 receptor stimulation. The significance of the inhibition of ATP by adenosine deaminase remains obscure since in purine metabolism the enzyme catalyzes the conversion of the haemodynamically active adenosine to inactive inosine.
对热带丽鱼科罗非鱼（尼罗口孵非鲫）离体灌注鳃对外源性应用腺苷和三磷酸腺苷（ATP）的血流动力学反应表明，这两种药物都是有效的血管活性物质。然而，虽然腺苷有血管收缩作用，但ATP诱导血管舒张。在存在腺苷脱氨酶和P1受体拮抗剂茶碱的情况下，ATP诱导的血管舒张被可逆性抑制，但不受P2受体拮抗剂奎尼丁的影响。这表明ATP通过刺激P1受体发挥特异性作用。腺苷脱氨酶对ATP的抑制作用的意义仍不清楚，因为在嘌呤代谢中，该酶催化具有血流动力学活性的腺苷转化为无活性的肌苷。
