Satchell D
Eur J Pharmacol. 1984 Jul 20;102(3-4):545-8. doi: 10.1016/0014-2999(84)90579-x.
ATP, adenosine, adenine and inosine exhibited similar potency in relaxing transverse strips of guinea-pig trachea. Dipyridamole potentiated responses to ATP and adenosine equally but antagonized responses to inosine and failed to affect responses to adenine. In dipyridamole-treated preparations, adenosine deaminase markedly reduced responses to ATP and adenosine; responses to adenine and inosine were unaffected. The results suggest that ATP acts via its adenosine metabolite and that inhibitory ATP receptors are absent.
ATP、腺苷、腺嘌呤和肌苷在舒张豚鼠气管横条方面表现出相似的效力。双嘧达莫对ATP和腺苷的反应增强作用相同，但拮抗对肌苷的反应，且不影响对腺嘌呤的反应。在双嘧达莫处理的标本中，腺苷脱氨酶显著降低了对ATP和腺苷的反应；对腺嘌呤和肌苷的反应未受影响。结果表明，ATP通过其腺苷代谢产物起作用，且不存在抑制性ATP受体。
