Raphas Co. Ltd, 62 Magokjungang 8-ro 1-gil Magok-dong, Gangseo-gu, Seoul, Republic of Korea.
Biomater Sci. 2018 Sep 25;6(10):2566-2570. doi: 10.1039/c8bm00768c.
We studied the role of the additives trehalose and poly(vinyl pyrrolidone) in the physical and pharmacokinetic properties of peptide drug incorporated hyaluronic acid microneedles. Poly(vinyl pyrrolidone) increases the mechanical strength of microneedles and ameliorates drug bioavailability in vivo, suggesting that poly(vinyl pyrrolidone) can be a promising additive in the fabrication of peptide drug-encapsulated fully dissolving microneedles.
我们研究了添加物海藻糖和聚乙烯吡咯烷酮在载肽透明质酸微针的物理和药代动力学性质中的作用。聚乙烯吡咯烷酮增加了微针的机械强度，并改善了体内药物的生物利用度，这表明聚乙烯吡咯烷酮可以成为制备载肽全溶解微针的有前途的添加剂。
