Huang Yiming, Yang Ping
Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu 730050, China.
Int J Anal Chem. 2022 May 23;2022:4565260. doi: 10.1155/2022/4565260. eCollection 2022.
The common feature of non-cross-linked hyaluronic acid nano-needles is that they penetrate the skin and dissolve rapidly, and the non-cross-linked hyaluronic acid will migrate under the skin, so it is difficult to maintain the long-term expansion effect in a fixed position. In order to achieve the relatively long-term antiwrinkle effect, a kind of cross-linked and non-cross-linked compound hyaluronic acid microne was prepared. By inserting the microne under the skin, dissolving the non-cross-linked part under the skin and introducing the cross-linked gel particles under the skin, the effect of extending the microne was achieved. The mechanical properties, permeability, and degradation rate of cross-linked and non-cross-linked hyaluronic acid composite nano-needles were studied in detail. Experimental results show that the higher the content of CHA, the slower the degradation rate of the microneedle, and the skin swelling of the HA_CHA (1 : 1) microneedle is the most lasting. With the increase of CHA content in microneedle matrix materials, the degree of epidermal expansion decreased. The preparation of cross-linked and non-cross-linked hyaluronic acid microneedles has the potential to be effectively used as dermal fillers in cosmetics or antiaging treatments.
非交联透明质酸纳米针的共同特点是它们能穿透皮肤并迅速溶解，且非交联透明质酸会在皮下迁移，因此难以在固定位置维持长期的扩张效果。为了实现相对长期的抗皱效果，制备了一种交联与非交联复合透明质酸微针。通过将微针插入皮下，使皮下的非交联部分溶解并在皮下引入交联凝胶颗粒，实现了延长微针效果。详细研究了交联与非交联透明质酸复合纳米针的力学性能、渗透性和降解速率。实验结果表明，CHA含量越高，微针的降解速率越慢，且HA_CHA（1∶1）微针的皮肤肿胀效果最持久。随着微针基质材料中CHA含量的增加，表皮扩张程度降低。交联与非交联透明质酸微针的制备有潜力在化妆品或抗衰老治疗中有效地用作真皮填充剂。
