Yasunaga T, Takahashi M, Uozumi H, Takada C, Kawano S, Baba Y, Nakamura I, Sonoda H, Matsukado Y
Acta Radiol Oncol. 1986 Jan-Feb;25(1):23-8. doi: 10.3109/02841868609136372.
Primary malignant lymphoma of the brain (PMLB) is uncommon. Between 1975 and 1982, the authors observed 11 patients with histologically confirmed PMLB. Mean survival after radiation therapy was 7 months with 5 patients surviving for more than 2 years. Multifocal lesions were seen in 9 patients and spontaneous regression was seen at computed tomography in 2 patients. Radiation doses in excess of 30 Gy controlled the primary tumor, but intracranial recurrences occurred even after whole brain irradiation to 40 Gy. Only one patient had a relapse outside the central nervous system, and none had clinical evidence of seeding to the spinal canal. The authors postulate that PMLB usually is a multifocal intracranial disease, and that whole brain irradiation of at least 30 to 40 Gy should be given to all patients with this disease.
原发性脑恶性淋巴瘤（PMLB）并不常见。1975年至1982年间，作者观察了11例经组织学确诊的PMLB患者。放疗后的平均生存期为7个月，5例患者存活超过2年。9例患者出现多灶性病变，2例患者在计算机断层扫描中出现自发消退。超过30 Gy的放射剂量可控制原发性肿瘤，但即使全脑照射至40 Gy后仍会发生颅内复发。只有1例患者在中枢神经系统外复发，且无一例有脊髓播散的临床证据。作者推测PMLB通常是一种多灶性颅内疾病，对于所有患有这种疾病的患者都应给予至少30至40 Gy的全脑照射。
