Ogawa T, Kanno I, Hatazawa J, Inugami A, Fujita H, Shimosegawa E, Murakami M, Okudera T, Uemura K, Yasui N
Department of Radiology and Nuclear Medicine, Research Institute of Brain and Blood Vessels, Akita, Japan.
Radiographics. 1994 Jan;14(1):101-10. doi: 10.1148/radiographics.14.1.8128041.
Positron emission tomography (PET) with carbon-11 methionine, computed tomography (CT), and magnetic resonance (MR) imaging were performed in 10 patients with histologically verified central nervous system (CNS) lymphoma before and after radiation therapy to compare the radiologic findings and to evaluate the usefulness of PET in monitoring tumor response to radiation therapy. Methionine PET clearly depicted CNS lymphoma before radiation therapy as an increased accumulation of C-11 methionine. The extent of increased accumulation of the radiotracer in tumor tissue markedly decreased after radiation therapy. The area of increased uptake was larger than the enhancing lesions on CT or MR images in most cases. One patient was confirmed to have tumor recurrence at the region of residual increased accumulation on methionine PET images. Methionine PET is useful for the delineation of CNS lymphoma and for monitoring the therapeutic effect of irradiation.
对10例经组织学证实的中枢神经系统（CNS）淋巴瘤患者在放疗前后进行了碳-11蛋氨酸正电子发射断层扫描（PET）、计算机断层扫描（CT）和磁共振（MR）成像，以比较影像学表现并评估PET在监测肿瘤对放疗反应中的作用。蛋氨酸PET在放疗前清晰显示CNS淋巴瘤为C-11蛋氨酸摄取增加。放疗后肿瘤组织中放射性示踪剂摄取增加的范围明显减小。在大多数情况下，摄取增加的区域大于CT或MR图像上的强化病变。1例患者在蛋氨酸PET图像上残留摄取增加的区域被证实有肿瘤复发。蛋氨酸PET有助于中枢神经系统淋巴瘤的勾画以及监测放疗的治疗效果。
