金催化的β-(2-氨基苯基)-α,β-炔酮与炔酰胺的级联反应:多取代 2-氨基喹啉的串联途径。
Gold-Catalyzed Cascade Reaction of β-(2-Aminophenyl)-α,β-ynones with Ynamides: A Sequential Route to Polysubstituted 2-Aminoquinolines.
机构信息
Dipartimento di Scienze Fisiche e Chimiche , Università di L'Aquila , Via Vetoio , 67010 Coppito (AQ) , Italy.
University Côte d'Azur, Institut de Chimie de Nice, UMR 7272 CNRS, Parc Valrose, Faculté des Sciences , 06100 Nice , France.
出版信息
Org Lett. 2018 Sep 7;20(17):5103-5106. doi: 10.1021/acs.orglett.8b01928. Epub 2018 Aug 14.
A novel, efficient, and mild synthetic route for the preparation of 2-aminoquinolines via a gold-catalyzed cascade reaction of β-(2-aminophenyl)-α,β-ynones with ynamides has been developed. This process tolerates a wide range of functionalities such as halogen, alkyl, aryl, and heteroaryl groups, leading to original heterocycles in fair to very good yields.
一种通过金催化β-(2-氨基苯基)-α,β-炔酮与炔酰胺的级联反应制备 2-氨基喹啉的新颖、高效、温和的合成路线已经开发出来。该过程能够容忍各种官能团，如卤素、烷基、芳基和杂芳基，从而以中等至非常好的产率得到原始杂环。
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