Orthopedics Research Institute of Chinese PLA, Beijing Key Lab of Regenerative Medicine in Orthopedics, General Hospital of Chinese PLA, Fuxing Road 28, Haidian District, Beijing 100853, PR China; Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan 030012, PR China.
Orthopedics Research Institute of Chinese PLA, Beijing Key Lab of Regenerative Medicine in Orthopedics, General Hospital of Chinese PLA, Fuxing Road 28, Haidian District, Beijing 100853, PR China.
Mech Ageing Dev. 2018 Oct;175:83-87. doi: 10.1016/j.mad.2018.08.002. Epub 2018 Aug 11.
In older adults, the prevalence of osteoarthritis (OA) increases directly with age and is the most common cause of chronic disability. It is necessary to recognize that OA is a degenerative disease that strongly correlates with age, and often promotes elevated levels of cartilage injury. Chondrocytes undergo an age-dependent decline in proliferative and synthetic capacity. It is thought that cellular senescence may play a significant role in the pathology of OA, with chondrocytes exhibiting a variety of senescence-associated phenotypes. In this review, we discuss cellular senescence and its relationship with OA. More importantly, we introduce novel strategies for the modulation of cellular senescence, including the use of sirtuin 6, mammalian target of rapamycin, N-acetyl-l-cysteine, proteoglycan-4 and senolytic, which may help to delay senescence and improve cartilage regeneration in the aging population.
在老年人中，骨关节炎（OA）的患病率随年龄增长而直接增加，是导致慢性残疾的最常见原因。需要认识到，OA 是一种退行性疾病，与年龄密切相关，常常导致软骨损伤水平升高。软骨细胞的增殖和合成能力随年龄的增长而下降。人们认为细胞衰老可能在 OA 的病理学中起重要作用，软骨细胞表现出多种与衰老相关的表型。在这篇综述中，我们讨论了细胞衰老及其与 OA 的关系。更重要的是，我们介绍了调节细胞衰老的新策略，包括使用 SIRT6、雷帕霉素靶蛋白、N-乙酰-L-半胱氨酸、蛋白聚糖 4 和衰老细胞溶解剂，这些策略可能有助于延缓衰老并改善老年人群的软骨再生。
