Gwam Chukwuweike, Ohanele Chiemena, Hamby Jacob, Chughtai Noor, Mufti Zarmina, Ma Xue
Department of Orthopedic Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Howard University College of Pharmacy, Washington, DC, USA.
Ann Transl Med. 2023 Jun 30;11(9):322. doi: 10.21037/atm.2019.10.20. Epub 2019 Oct 16.
Osteoarthritis (OA) is a degenerative joint disease marked by cartilage degradation and loss of function. Recently, there have been increased efforts to attenuate and reverse OA by stimulating cartilage regeneration and preventing cartilage degradation. Human placental extract (HPE) may be an option due to its anti-inflammatory, antioxidant, and growth stimulatory properties. These properties are useful in preventing cell death and senescence, which may optimize cartilage regeneration. In this review, we discuss the anatomy and physiology of the placenta, as well as explore and studies assessing its effects on tissue regeneration. Finally, we assess the potential role of HPE in cartilage regenerative medicine and OA. The Medline database was utilized for all studies that involved the use of HPE or human placenta hydrolysate. Exclusion criteria included articles not written in English, conference reviews, editorials, letters to the editor, surveys, case reports, and case series. HPE had significant anti-inflammatory and regenerative properties and . Furthermore, HPE had a role in attenuating cellular senescence and cell apoptosis via reduction of reactive oxidative species both and . One study explored the effects of HPE in OA and demonstrated reduction in cartilage catabolic gene expression, indicating HPE's effect in attenuating OA. HPE houses favorable properties that can attenuate and reverse tissue damage. This may be a beneficial therapeutic in OA as it creates a more favorable environment for cartilage regeneration. More well designed and studies are needed to define the role of HPE in treating OA.
骨关节炎（OA）是一种以软骨退化和功能丧失为特征的退行性关节疾病。最近，人们加大了通过刺激软骨再生和防止软骨退化来减轻和逆转OA的努力。人胎盘提取物（HPE）因其抗炎、抗氧化和生长刺激特性可能是一种选择。这些特性有助于预防细胞死亡和衰老，从而可能优化软骨再生。在本综述中，我们讨论了胎盘的解剖结构和生理学，以及探索和评估其对组织再生影响的研究。最后，我们评估了HPE在软骨再生医学和OA中的潜在作用。所有涉及使用HPE或人胎盘水解物的研究均使用了Medline数据库。排除标准包括非英文撰写的文章、会议综述、社论、给编辑的信、调查、病例报告和病例系列。HPE具有显著的抗炎和再生特性。此外，HPE通过减少活性氧化物质在减轻细胞衰老和细胞凋亡方面发挥作用。一项研究探讨了HPE对OA的影响，结果表明软骨分解代谢基因表达降低，这表明HPE在减轻OA方面的作用。HPE具有可减轻和逆转组织损伤的有利特性。这在OA中可能是一种有益的治疗方法，因为它为软骨再生创造了更有利的环境。需要更多设计良好的研究来确定HPE在治疗OA中的作用。
