Wang Wenzhu, Liu Lixu, Chen Chen, Jiang Peng, Zhang Tong
Institute of Rehabilitation Medicine of China, China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing, PR China; Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, PR China.
School of Rehabilitation, Capital Medical University, Beijing, PR China; Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing, PR China; Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, PR China.
Neurosci Lett. 2018 Sep 25;684:181-186. doi: 10.1016/j.neulet.2018.08.011. Epub 2018 Aug 11.
Global cerebral ischemia-reperfusion (GCI/R) may occur after any of several clinical conditions such as cardiac arrest and anesthetic accident. Some dopamine receptor agonists possess neuroprotective effects. However, some of them may produce side effects during treatment. Piribedil, which is a dopamine D2/D3 receptor agonist, has fewer side effects and is well tolerated. This study investigated the effects of piribedil on learning and memory of rats with GCI/R according to modified neurological severity score (mNSS) scoring and Morris water maze test (MWM). Rats with GCI/R were treated with piribedil 25 or 50 mg/kg/d, and mNSS was performed at 6 h, 1 day, 3 days, and 1 and 2 weeks after injury. The MWM test was employed to evaluate learning and memory of rats at 1 and 2 weeks after injury. The results showed treatment with piribedil reduced the mNSS score and prolonged the time in the target quadrant compared with untreated rats although no obvious differences of the 25 and 50 mg/kg/d piribedil intervention groups were observed statistically. Piribedil is effective in improving the neurological function and learning and memory of rats after GCI/R.
全脑缺血再灌注（GCI/R）可能发生在心脏骤停和麻醉意外等多种临床情况之后。一些多巴胺受体激动剂具有神经保护作用。然而，其中一些在治疗过程中可能会产生副作用。吡贝地尔是一种多巴胺D2/D3受体激动剂，副作用较少且耐受性良好。本研究根据改良神经功能缺损评分（mNSS）和莫里斯水迷宫试验（MWM），研究了吡贝地尔对GCI/R大鼠学习和记忆的影响。GCI/R大鼠分别接受25或50 mg/kg/d的吡贝地尔治疗，并在损伤后6小时、1天、3天以及1周和2周时进行mNSS评分。MWM试验用于评估损伤后1周和2周时大鼠的学习和记忆能力。结果显示，与未治疗的大鼠相比，吡贝地尔治疗可降低mNSS评分，并延长在目标象限的停留时间，尽管25和50 mg/kg/d吡贝地尔干预组之间在统计学上未观察到明显差异。吡贝地尔可有效改善GCI/R大鼠的神经功能以及学习和记忆能力。
