Caldwell M A, Reymann J M, Bentue-Ferrer D, Allain H, Leonard B E
Department of Pharmacology, University College Galway, Ireland.
Neuropsychobiology. 1996;34(3):117-24. doi: 10.1159/000119302.
The 4-vessel occlusion model of ischaemia in the rat was used to assess the effects of two dopaminergic agonists, lisuride and piribedil, on some behavioural and histological changes. Animals were either sham-operated, subjected to 20 min 4-vessel occlusion, or administered lisuride (0.5 mg/kg i.p.) or piribedil (10 mg/kg i.p.) 1 h before 20 min 4-vessel occlusion. Both drugs attenuated deficits in neurological testing, Morris water maze and 14-unit T-maze (p < 0.05). Extensive neuronal death was observed in the CA1, CA3 and CA4 regions of the hippocampus of 4-vessel-occluded animals. Pretreatment with both lisuride and piribedil provided protection against cell death in the hippocampal regions. These findings suggest dopamine may play a role in cerebral ischaemia and dopaminergic agonists may be beneficial in preventing ischaemia-induced neurodegeneration.
采用大鼠四血管闭塞缺血模型，评估两种多巴胺能激动剂——利苏力特和吡贝地尔对一些行为和组织学变化的影响。动物分为假手术组、接受20分钟四血管闭塞组，或在20分钟四血管闭塞前1小时腹腔注射利苏力特（0.5毫克/千克）或吡贝地尔（10毫克/千克）组。两种药物均减轻了神经测试、莫里斯水迷宫和14单元T迷宫中的缺陷（p<0.05）。在四血管闭塞动物的海马体CA1、CA3和CA4区域观察到广泛的神经元死亡。利苏力特和吡贝地尔预处理均能保护海马区细胞免于死亡。这些发现表明多巴胺可能在脑缺血中起作用，多巴胺能激动剂可能有助于预防缺血性神经退行性变。
