Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
School of Medicine, Flinders University, Adelaide, Australia.
Am J Cardiol. 2018 Oct 15;122(8):1352-1358. doi: 10.1016/j.amjcard.2018.06.046. Epub 2018 Aug 11.
Although a high level of alcohol consumption is associated with cardiomyopathy, the benefit or risk of moderate alcohol consumption on incident heart failure (HF) is unknown. This study examined the association between alcohol consumption and risk for HF in older adults with hypertension. The study analyzed data from a cohort of 6,083 participants aged 65 to 84 years at baseline (1995 to 2001) followed for a median of 10.8 years during and after the Second Australian National Blood Pressure Study. Frequency and amount of alcohol consumption were self-reported at baseline and during the clinical trial. The percentages of current drinkers, former drinkers, and never-drinkers at baseline were 4,400 (72%), 394 (6%), and 1,289 (21%), respectively. Incident HF was diagnosed in 183 men and 136 women. After adjustment for multiple confounders, alcohol consumption was not significantly associated with HF. Compared with never-drinkers, the adjusted hazard ratios (95% confidence interval) for those who consume 1 to 7, 8 to 14, and >14 drinks/week at baseline were 0.87 (0.59 to 1.30), 0.96 (0.57 to 1.60), and 0.71 (0.25 to 2.02), respectively in women, and 0.81 (0.47 to 1.38), 0.77 (0.43 to 1.38), and 1.04 (0.59 to 1.84), respectively in men. The findings of lack of an association between alcohol consumption and risk of HF persisted in the analyses comparing the risk of HF across each level of drinking at baseline or at follow-up with never-drinkers. In the present study, there was no evidence for benefit or risk of alcohol consumption, reported at baseline or at follow-up, in relation to incident HF in both men and women.
尽管大量饮酒与心肌病有关，但适量饮酒对心力衰竭（HF）发病的益处或风险尚不清楚。本研究旨在探讨老年高血压患者饮酒与 HF 风险之间的关系。该研究分析了基线时年龄为 65 至 84 岁的 6083 名参与者的数据，这些参与者来自于第二次澳大利亚国家血压研究（1995 至 2001 年），并在随后的中位 10.8 年时间内进行了随访，包括临床试验期间。基线时和临床试验期间，通过自我报告来记录饮酒频率和饮酒量。基线时当前饮酒者、既往饮酒者和从不饮酒者的比例分别为 4400 人（72%）、394 人（6%）和 1289 人（21%）。共有 183 名男性和 136 名女性被诊断为 HF。在调整了多种混杂因素后，饮酒与 HF 无显著相关性。与从不饮酒者相比，基线时每周饮酒 1 至 7 杯、8 至 14 杯和 >14 杯的女性调整后的 HR（95%CI）分别为 0.87（0.59 至 1.30）、0.96（0.57 至 1.60）和 0.71（0.25 至 2.02），男性分别为 0.81（0.47 至 1.38）、0.77（0.43 至 1.38）和 1.04（0.59 至 1.84）。在按基线或随访时每个饮酒水平比较 HF 风险的分析中，也没有发现饮酒与 HF 风险之间存在关联。在本研究中，无论男性还是女性，在基线或随访时报告的饮酒与 HF 发病之间均无获益或风险的证据。
