Department of Acute Respiratory Medicine and Thoracic Oncology, Lyon Sud Hospital, Pierre Bénite, France; EMR 3738 "Therapeutic Targeting in Oncology", Faculty of Medicine, Lyon-Sud-Charles Mérieux, Pierre Bénite, France.
Department of Multidisciplinary Oncology and Therapeutic Innovations, Aix Marseille University, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
Clin Lung Cancer. 2018 Nov;19(6):493-501. doi: 10.1016/j.cllc.2018.07.001. Epub 2018 Jul 6.
Lung cancer (LC) screening (LCS) with annual low-dose computed tomography scans has been seen to reduce the specific and overall mortality in selected populations. However, participation is key to successful screening programs. The EDIFICE (etude sur le dépistage des cancers et ses facteurs de compliance [survey on cancer screening and compliance factors]) nationwide observational surveys are used to assess behavior related to cancer screening programs in France.
Using comprehensive multivariate stepwise logistic regression analyses of data from current and former cigarette smokers, we sought to identify the explanatory factors associated with the intention to participate in an LCS program.
Of the 1463 respondents with no personal history of cancer, 263 (36.4%) of the current cigarette smokers and 170 (26.3%) of the former cigarette smokers stated their willingness to participate in an LCS program. The explanatory factors differed between current cigarette smokers (already screened for LC: odds ratio [OR], 2.81; < 30 pack-years: OR, 2.69; intention to quit smoking: OR, 1.96; no social vulnerability: OR, 2.15) and former cigarette smokers (comorbidities: OR, 0.31). The usual eligibility criteria were not significantly explanatory.
Our findings highlight the discrepancy that exists between target populations and individuals who actually intend to participate in a screening program for LC, with subsequent potential effects on the participation rates and, thus, on the efficacy of screening.
每年进行低剂量计算机断层扫描的肺癌（LC）筛查（LCS）已被证明可以降低选定人群的特定和总体死亡率。然而，参与是成功筛查计划的关键。EDIFICE（癌症筛查及其依从性研究[关于癌症筛查和依从性因素的调查]）全国性观察性调查用于评估法国与癌症筛查计划相关的行为。
我们使用当前和以前的吸烟者数据进行综合多变量逐步逻辑回归分析，旨在确定与参与 LCS 计划的意向相关的解释因素。
在 1463 名无个人癌症史的受访者中，263 名（36.4%）当前吸烟者和 170 名（26.3%）以前吸烟者表示愿意参加 LCS 计划。解释因素在当前吸烟者（已筛查 LC：优势比 [OR]，2.81；<30 包年：OR，2.69；戒烟意向：OR，1.96；无社会脆弱性：OR，2.15）和以前吸烟者（合并症：OR，0.31）之间存在差异。通常的合格标准没有明显的解释性。
我们的研究结果强调了目标人群与实际有意参加 LC 筛查计划的个体之间存在差异，这可能对参与率产生潜在影响，进而影响筛查的效果。
