Huang Lining, Jiang Xingming, Wang Zhidong, Zhong Xiangyu, Tai Sheng, Cui Yunfu
Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang, China.
Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang, China.
Pathol Res Pract. 2018 Sep;214(9):1247-1252. doi: 10.1016/j.prp.2018.07.033. Epub 2018 Aug 2.
Long non-coding RNAs (lncRNAs), a group of transcripts with length greater than 200 nucleotides, have been involved in multiple pathophysiological processes of the human body, especially in tumorigenesis and progression of cancers. The aberrant expression of lncRNAs processes crucial functions involved in proliferation, apoptosis and metastatic capacity of cancers. Recent studies have revealed that small nucleolar RNA host gene 1 (SNHG1), a long non-coding RNA transcribed from UHG, was located in chromosome 11. Aberrant expression of SNHG1 has been demonstrated to be associated with various sites of cancers such as glioma, esophageal cancer, gastric cancer and many others, and its deregulation could be related to survival and prognosis of cancer patients. Pertinent to clinical practice, SNHG1 might act as a prognostic biomarker for tumors and might even serve as potential target for therapy. In this review, we summarized current researches concerning the role of SNHG1 in tumor progression and discussed its mechanisms involved.
In this review, we summarized and figured out recent studies concerning the expression and biological mechanisms of SNHG1in tumor development. The related studies were obtained through a systematic search of PubMed, Embase and Cochrane Library.
SNHG1 was a valuable cancer-related lncRNA that the expression level was up-regulation in a variety of malignancies, including glioma, esophageal cancer, lung cancer, gastric cancer, hepatocellular carcinoma, colorectal carcinoma, prostate cancer, cervical cancer, osteosarcoma, neuroblastoma, nasopharyngeal carcinoma. The aberrant expressions of SNHG1 have shown to contribute to proliferation, migration, and invasion of cancer cells.
SNHG1 represents promising novel biomarkers for various cancer types and have a great potential to be effectively used in clinical practice in the near future.
长链非编码RNA（lncRNAs）是一组长度大于200个核苷酸的转录本，参与人体多种病理生理过程，尤其是癌症的发生和发展。lncRNAs的异常表达在癌症的增殖、凋亡和转移能力中发挥关键作用。最近的研究表明，小核仁RNA宿主基因1（SNHG1）是一种从UHG转录而来的长链非编码RNA，位于11号染色体上。SNHG1的异常表达已被证明与多种癌症部位相关，如胶质瘤、食管癌、胃癌等，其失调可能与癌症患者的生存和预后有关。与临床实践相关的是，SNHG1可能作为肿瘤的预后生物标志物，甚至可能成为潜在的治疗靶点。在本综述中，我们总结了目前关于SNHG1在肿瘤进展中作用的研究，并讨论了其相关机制。
在本综述中，我们总结并梳理了关于SNHG1在肿瘤发生发展中的表达及生物学机制的最新研究。相关研究通过系统检索PubMed、Embase和Cochrane图书馆获得。
SNHG1是一种与癌症相关的重要lncRNA，其表达水平在多种恶性肿瘤中上调，包括胶质瘤、食管癌、肺癌、胃癌、肝细胞癌、结直肠癌、前列腺癌、宫颈癌、骨肉瘤、神经母细胞瘤、鼻咽癌。SNHG1的异常表达已显示出促进癌细胞的增殖、迁移和侵袭。
SNHG1是各种癌症类型有前景的新型生物标志物，在不久的将来有很大潜力有效地应用于临床实践。
