长链非编码 RNA FOXD2-AS1 的致癌性及其在人类癌症中的分子机制。
Oncogenicity of lncRNA FOXD2-AS1 and its molecular mechanisms in human cancers.
机构信息
Department of Hepatobiliary Surgery, Heilongjiang Province Second Cancer Hospital, Harbin 150088, China.
Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
出版信息
Pathol Res Pract. 2019 May;215(5):843-848. doi: 10.1016/j.prp.2019.01.033. Epub 2019 Jan 29.
OBJECTIVES
Long non-coding RNAs (lncRNAs) are a group of noncoding RNAs with length larger than 200 nucleotides. LncRNAs have limited or no protein-coding capacity because of lack of obvious open reading frame. An increasing number of researches have shown that lncRNAs participate in the complex regulation network of cancer and play an important role in tumourigenesis and progression such as proliferation, migration and invasion. LncRNA FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1), located on chromosome 1p33 and with a transcript length of 2527 nucleotides, is a novel cancer-related lncRNA. FOXD2-AS1 was recently found to exhibit aberrant expression in various malignancies, including gastric, lung, bladder, colorectal, nasopharyngeal, esophageal, hepatocellular, thyroid and skin cancer, and its deregulation might be related to survival and prognosis of cancer patients. Pertinent to clinical practice, FOXD2-AS1 might act as a feasible biomarker or therapeutic target in human cancers. In this paper, we made a summary on the current findings concerning the biological functions and molecular mechanisms of FOXD2-AS1 in tumor progression.
MATERIALS AND METHODS
In this paper, we summarized and figured out recent studies about the expression and molecular biological mechanisms of FOXD2-AS1 in tumor progression. Existing relevant studies were obtained through a systematic search from PubMed, Embase, BioMedNet, GEO database and Cochrane Library.
RESULTS
FOXD2-AS1 was a valuable tumor-associated lncRNA. Its expression level was up-regulation in various malignancies, including gastric, lung, bladder, colorectal, nasopharyngeal, esophageal, hepatocellular, thyroid and skin cancer. In addition, the aberrant expressions of FOXD2-AS1 have shown to contribute to proliferation, migration and invasion of cancer cells, and its deregulation is related to carcinogensis, overall survival, disease free survival, prognosis and tumor progression.
CONCLUSIONS
LncRNA FOXD2-AS1 is an oncogene and probably represents a feasible biomarker or therapeutic target in human cancers.
目的
长链非编码 RNA（lncRNA）是一组长度大于 200 个核苷酸的非编码 RNA。由于缺乏明显的开放阅读框，lncRNA 的蛋白编码能力有限或没有。越来越多的研究表明，lncRNA 参与癌症的复杂调控网络，并在肿瘤发生和发展中发挥重要作用，如增殖、迁移和侵袭。位于 1p33 染色体上，转录本长度为 2527 个核苷酸的新型癌相关 lncRNA FOXD2 反义链 RNA1（FOXD2-AS1）。最近发现，FOXD2-AS1 在多种恶性肿瘤中表达异常，包括胃癌、肺癌、膀胱癌、结直肠癌、鼻咽癌、食管癌、肝癌、甲状腺癌和皮肤癌，其失调可能与癌症患者的生存和预后有关。与临床实践相关的是，FOXD2-AS1 可能是人类癌症中一种可行的生物标志物或治疗靶点。本文对 FOXD2-AS1 在肿瘤进展中的生物学功能和分子机制的最新研究结果进行了总结。
材料与方法
本文总结并阐述了 FOXD2-AS1 在肿瘤进展中的表达及分子生物学机制的相关研究。通过系统检索 PubMed、Embase、BioMedNet、GEO 数据库和 Cochrane Library 等数据库，获取了现有相关研究。
结果
FOXD2-AS1 是一种有价值的肿瘤相关 lncRNA。在包括胃癌、肺癌、膀胱癌、结直肠癌、鼻咽癌、食管癌、肝癌、甲状腺癌和皮肤癌在内的多种恶性肿瘤中，其表达水平上调。此外，FOXD2-AS1 的异常表达促进了癌细胞的增殖、迁移和侵袭，其失调与肿瘤发生、总生存期、无病生存期、预后和肿瘤进展有关。
结论
lncRNA FOXD2-AS1 是一种癌基因，可能是人类癌症中一种可行的生物标志物或治疗靶点。
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